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Protein phosphorylation is a crucial component in physiological signal transduction pathways. It is estimated that one-third of all cellular proteins are modified through phosphorylation, and these pathways are regulated by kinase and phosphatase enzymes. Glucose-6-phosphatase (…
An approach toward the synthesis of FK-506 is described. The strategy is convergent, and disconnects the macrocycle into four manageable subunits; phosphonate 85, aldehyde 86, bromide 87 and aldehyde 88. An efficient synthesis of aldehyde 86 and its elaboration to bromide 83 is …