The lasso and its successor, the elastic net, are two popular regularized regression methods which produce sparse models. We propose two different extensions to these methods that leverage feature information in the model-fitting process to improve predictive accuracy. The first…
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Prostate Cancer (PCa) is a non-cutaneous malignancy in men. Considering the severity of the disease, it is essential to consider the early detection and screening of prostate-specific antigen for decreasing the incidence of death due to this disease. Decipher is a genomic test t…
Since their discovery, the BRCA1 and BRCA2 genes have garnered the attention of many, as related news and access to genetic testing became more available to the public. Considering the public’s increasing awareness of breast cancer and access to BRCA genetic testing, individuals…
Prostate cancer is the second most common cancer in men worldwide. Of almost 1.3 million newly diagnosed men per year, up to 80% will have localized disease with a characteristically prolonged natural history. Risk stratification and treatment decision-making for these men is cu…
Background: Prostate Cancer (PCa) is the second most common malignancy among men in the world. In Sweden about 10,000 new cases are diagnosed each year. Mortality rates have been rather stable but have declined the past decades due to early diagnosis and treatment at the expense…
Dynamic treatment regimes (DTRs) have gained increasing interest in the field of personalized health care in the last two decades, as they provide a sequence of individualized decision rules for treating patients over time. In a DTR, treatment is adapted in response to the chang…
This study explored the experiences, psychosocial needs and how best to address them after prostate cancer treatment for Black African/Black Caribbean men and their partners in England. Cancer statistics in the United Kingdom show that Black African and Black Caribbean men have …
Replication-selective oncolytic adenoviruses represent a promising anticancer approach with proven efficacy in cancer cell lines and tumour xenografts in vivo. Anti-tumour efficacy, both in preclinical studies and clinical trials, was significantly improved in combination with c…
Prostate cancer (PCa) is a unique and controversial disease. This is at least due to the high prevalence of latent disease, increasing amounts of which is being diagnosed, most of which is indolent and not lead to death, and for which treatment carries significant risks. An incr…
The potential of using FTIR imaging as analytical technique combined with pre-processing and multivariate analysis methods was investigated. FTIR spectroscopy has been used in the past to investigate aspects of prostate cancer cells and tissues, successfully showing the separati…
The feasibility of Fourier transform infrared (FTIR)-imaging spectroscopy as a tool to discriminate samples from patients suffering from benign prostatic hyperplasia (BPH) and prostate cancer (CaP) samples in blood serum was investigated. Prostate cancer is known to be an age re…
Background: African Heritage (AH) men have a higher overall incidence, earlier age of onset, more clinically advanced and aggressive disease, higher incidence of metastases and mortality from prostate cancer (CaP) compared to Caucasian men. Biological and genetic factors relatin…
Disease progression manifests through a broad spectrum of statically and longitudinally linked clinical features and outcomes. This leads to heterogeneous progression patterns that may vary greatly across individual patients and makes the survival and quality of a patient’s life…
With around 1.2 million cases per year, prostate cancer is the second most common cancer among men. It is usually a slow growing disease that affects older men. It is also a cancer that is heterogenous, often multifocal, and rarely show symptoms as long as it is localized. All t…
The growth-inhibitory effect of saw palmetto supplements (SPS) with high long-chain fatty acids (FA)-low phytosterols (HLLP), high long-chain FA-high phytosterols (HLHP), and high medium-chain FA-low phytosterols (HMLP) was determined using androgen-sensitive LNCaP prostate canc…
Magnetic nanoparticles (MNPs) were synthesized from Fe2+ and Fe3+ by the co-precipitation method. Two nanoparticle surface coatings (gum arabic and sodium citrate) provided additional functionalization and cell selectivity. The incorporation of surface modifiers to the synthesiz…
Fish from the Great Lakes are a potential source of persistent organic pollutants, including polychlorinated biphenyls (PCBs) and organochlorine pesticides (e.g., Mirex and DDT). However, fish are also a source of micro- and macro- nutrients hypothesized to have chemopreventive …
Boron neutron capture therapy (BNCT) for the treatment of prostate cancer using a boron-containing cholesteryl ester compound (BCH) was investigated. BNCT is a binary radiation therapy that relies on targeted delivery of 10B to cancer cells followed by irradiation with thermal n…
Vitamin D3 (VD3) is a fat soluble secosteroid obtained primarily through ultraviolet-B dependent synthesis in the skin. VD3 has antitumor effects and has been suggested to reduce risk of non-skin cancers. The vitamin D receptor (VDR) has shown inconsistent association with prost…