The accurate distribution of a fully replicated, intact genome perhaps defines the purpose of the cell cycle, which is a complex, organized series of events pertaining to the production of daughter cells. Every eukaryotic cell undergoes two alternative life cycles mitosis or mei…
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Salmonella species can cause wide-ranging disease from mild food-poisoning enteritis to a systemic, sometimes fatal typhoid infection. These bacteria have evolved to survive in different environments within and outside the host and do so through the regulation of differential ge…
Abstract Human cytomegalovirus (HCMV) is a highly host-specific, ubiquitous herpesvirus that results in asymptomatic infection for the majority of those infected. However, it produces serious clinical disease in neonates and immunocompromised individuals such as transplant recip…
Myotonic dystrophy type 1 (DM1) is the most common form of muscular dystrophy in adults, characterised by multiple tissue involvement and caused by an expansion of a (CTG)n repeat within the 3’-UTR of the DMPK gene (19q13.3). Normal individuals contain between 5 and 35 CTG repea…
CD23 is a Type II glycoprotein that exists in both membrane-bound (mbCD23) and soluble (sCD23) forms and functions as the low affinity receptor for IgE. CD23 interacts with a range of proteins to fulfil its function in vivo. Through interactions with its ligands IgE and CD21, CD…
The principal aim of this thesis was to investigate the ability of surface topography in inducing bone cell differentiation for biomedical purposes. In orthopedic research, regeneration of bone defects can be performed in vitro using biomaterials. Third generation biomaterials a…
Stomatins belong to the band-7 (or SPFH domain) family (short for Stomatin, Prohibitin, Flotillin HflC/K) of diverse membrane proteins. This protein family is evolutionary conserved with members found in all sequenced eukaryotes and in most prokaryotes. Band-7 family proteins ha…
Purine transport in malaria parasites has become an important potential drug target because the malaria parasite is unable to synthesis purine de novo and has to salvage it from the host milieu through transporter(s). Knowledge of the number, selectivity and kinetic parameters o…
cAMP is a secondary messenger that is involved in a variety of signalling pathways through its effectors including EPAC, PKA and ion channels. cAMP signalling regulates processes such as memory, muscle contraction and inflammatory responses. PDE enzymes offer a mechanism to nega…
Leishmania species are protozoan parasites which have a complex life cycle, which is coordinated with its cell cycle. There are 11 cyclin dependent kinases (CDKs) and 11 cyclins present in the Leishmania genome reflecting the complexity of cell cycle control in this parasite, pe…
We study approaches for finding good solutions, and lower bounds, for three difficult combinatorial optimisation problems. The supply ship travelling salesman problem is a simplification of a situation faced by a naval logistics coordinator who must direct a support vessel taske…
Protozoan parasites of the genus Plasmodium are the causative agent of malaria. The four human pathogenic species infect more than 500 million people each year, causing the death of at least 1 million people. The most severe form of human malaria is caused by P. falciparum, whic…
This is a general investigation of the SPECT imaging process. The primary aim is to determine the manner in which the SPECT studies should be performed in order to maximise the relevant clinical information given the characteristics and limitations of the particular gamma camera…
This thesis aims to investigate the use of two materials: rockdust and greenwaste compost for use as soil fertility amendments. A field trial was conducted over three years to investigate the impact these materials had on plant yield, plant nutrient content, soil chemistry and s…
Rheumatoid arthritis (RA) is an inflammatory autoimmune disease characterized by chronic inflammation within the synovial tissues in multiple joints leading to progressive, erosive destruction of cartilage and underlying joints. The severity of RA is associated with the overexpr…
Peptidases of Leishmania are acknowledged virulence factors. It is hypothesised that peptidases are crucial for the survival of Leishmania in its hosts and that many could be potential targets for new antileishmanial drugs. As such, the investigation of peptidase activity in liv…
Glomerulonephritis (GN) is a major cause of progressive chronic renal failure (CRF) and accounts for less than 20% in the UK of patients requiring dialysis and transplantation. There are many forms of GN, of which IgA nephropathy (IgAN) is the most common, affecting up to 2% of …
The investigation of strongly hydrogen bonded solid state materials and the hydrogen transfer processes therein are the subject of the present work. Strong hydrogen bonds are found whenever the hydrogen bonded species compete for the hydrogen atom, and are thereby on the verge o…
CD23 is a multi-functional protein which exists in membrane-bound and soluble forms. Its functions include acting as the low affinity receptor for IgE and generating pro-inflammatory cytokine release in monocytes. CD23 has been found to interact with αvβ5 and this interaction gr…