Melanocytes within benign human nevi are the paradigm for tumor suppressive senescent cells in a pre-malignant neoplasm. These cells typically contain mutations in either the BRAF or NRAS oncogene and express markers of senescence, including p16INK4A 1-4. However, a nevus can co…
"377" Result
Sort By:
fruitless (fru) is a pleiotropic gene which produces an array of variant transcription factor isoforms to fulfil a range of developmental and behavioural roles, from the regulation of axonal pathfinding during embryogenesis, all the way to the precise orchestration of individual…
Nano-biotechnology combines recent advances in nanotechnology with biology. It is a relatively new discipline and full of promise. One such promise is the elucidation of complex bio-molecular reactions and interactions, the elucidation of which requires the development of reliab…
Active Screen Plasma Nitriding (ASPN) is a novel surface engineering technique, the main advantage of which is the capacity to treat homogeneously all kind of materials surfaces of any shape. Here, ASPN is used to modify the surface properties of ionomer glasses and polymers in …
Supercritical carbon dioxide (SC-CO\(_2\)) and Soxhlet extraction using hexane as solvent were used to extract 2-acetyl-1-pyrroline (2-AP) from Pandan leaves. The effect of different extraction pre-treatments, such as particle size and drying on the extraction yield and concentr…
Low temperature plasma surface alloying with nitrogen (nitriding), carbon (carburising) and both (carbonitriding) has been successfully employed in hardening medical grade ASTM F138, ASTM F1586 and ASTM F2581 as well as engineering grade AISI 316 by the formation of a modified l…
Chk1 is a conserved protein kinase which is activated in response to multiple exogenous and endogenous genotoxic stresses. In response Chk1 mediates several cell cycle checkpoint responses which are important components of the cellular DNA damage response (DDR) pathway and as su…
Trypanosoma brucei spp. are protozoan parasites that cause Human African Sleeping Sickness and Nagana, a disease of cattle. The diseases have a very high mortality rate if untreated and the current drug treatments are inadequate due to toxicity and resistance. In order to develo…
Unlike the rest of Britain, Scotland has no native crayfish species. There are, however, two introduced species: the white-clawed crayfish (Austropotamobius pallipes) has inhabited Loch Croispol in Sutherland and Whitemoss Reservoir in Renfrewshire for several decades. A. pallip…
Bacterial mechanosensitive (MS) channels represent the most primitive form of MS channels gating solely in response to changes in bilayer tension. The two main families of bacterial MS channels are MscS and MscL. In concert these channels are imperative to obviate the effects of…
Nigeria has serious environmental degradation resulting from pollution related to the oil and gas industry. The Department of Petroleum Resources reports that there were over 4,200 oil spill incidences in Nigeria over the last 50 years, ranging from minor spills to over half a m…
CaMKII acts as a second messenger to Ca2+ signals within the cardiac myocyte. Cellular stresses such as ischaemia and subsequent reperfusion perturb the normal physiological oscillations of Ca2+ to cause an escalating concentration which damages the cell. CaMKII has been implica…
Irritable bowel syndrome is one of the most common problems reported to general practitioners and gastroenterologists. It has been shown that many of the gut and systemic symptoms are due to lactose sensitivity, the sugar found mainly in milk. Undigested carbohydrates and other …
In the treatment of pre-menopausal women with oestrogen positive (ER+) breast cancer, tamoxifen represents a first line of adjuvant treatment with demonstrable benefits. Despite this, resistance is frequently acquired to tamoxifen with an associated poor prognosis. Breast cancer…
The innate immune system is a vital part of the body's defences against viral pathogens. RIG-I and MDA5 belong to the retinoic acid inducible gene-I (RIG-I)-like receptors (RLRs) family and function as cytoplasmic PRRs that are involved in the elimination of actively replicating…
The Lost Foam Casting process has been firmly established for Aluminium and ferrous alloys. This process offers many advantages over conventional casting processes but its full potential has yet to be reached due to the many defects introduced to the casting associated with deco…
The main objective of this research was to understand phenomena occurring during food digestion and nutrients absorption in the small intestine from an engineering perspective. Intestinal flow and mixing processes were simulated using a dynamic in vitro Small Intestine Model (SI…
Background: Patient recruitment to trials is problematic; many fail to achieve targets, leaving them underpowered and unable to address their hypothesis. Few solutions have been identified in existing literature. This thesis aimed to: identify factors associated with recruitment…
The Brown Plant Hopper (BPH) is a serious pest of rice in Asia. Development of novel control strategies can be facilitated by a comparison of BPH feeding behaviour on varieties exhibiting natural genetic variation, and then an elucidation of the underlying mechanisms of resistan…