This work describes the controlled organocatalytic ring-opening polymerisation (ROP) of cyclic carbonates with pendant groups for the preparation of functional aliphatic poly(carbonate)s and poly(estercarbonate) s. Their subsequent post-polymerisation functionalisations were stu…
"562" Result
Sort By:
This thesis describes the development of new methods for the synthesis of mono-, diand trihydroxylated tetrahydroxanthones which are structural elements of a range of important natural products including the anti-cancer agents known as the kigamicins. In Chapter One, work on the…
Verdazyl Radicals as Mediators in Living Radical Polymerisation: The aim of this work was to investigate verdazyl radicals as an alternative to nitroxides as mediators in stable free radical polymerisation. Verdazyl radicals and their unimolecular initiators were synthesised and…
Cisplatin has been used to treat various types of cancers for over 30 years, however, a number of serious side-effects of cisplatin have stimulated the quest for other metal-based anticancer agents. Iridium complexes are generally thought to be too inert to possess high reactivi…
Biological macromolecules are becoming increasingly important as a target for pharmaceutical research. Structural examination of this class of compounds is vital, both in terms of understanding the three-dimensional structures these molecules form as well as for quality control …
The objective of this thesis was to investigate the synthesis of well defined star polymers utilising controlled radical polymerisation techniques for potential use as viscosity modifiers in Engine oils. Recent developments in the characterisation of star polymers using multi-de…
The overall aim of this thesis was to examine the kinetics of proton-promoted dissolution of the dental hard tissue enamel as a non-bacterial process and the evaluation of inhibitors with the intent of minimising the dissolution process and effectively protecting the surface. A …
This work presents investigations into the use of the near-infrared (NIR) signals to interrogate, detect and image specific chemical compounds of interest in a security screening application, including when such compounds are hidden behind single layers of clothing fabric. In an…
The work presented in this thesis is concerned with the growth and characterisation of III-NSb films by plasma-assisted molecular beam epitaxy (PA-MBE). The research was motivated by their application in technologically important regions of the IR spectrum. Homoepitaxial growth …
Epitaxial growth of NiSb on GaAs(111)B substrates has been achieved for the first time. X-ray diffraction confirms the films are of high quality and oriented (0001) with respect to the (111) substrate. Surface reconstructions have been observed on NiSb thin films through electro…
The aim of this project lied in the development of an Evolvable Process Design (EPD) reactor platform such that 'evolved' chemical reactions could be investigated for the first time. The development of this 'machine' would allow us to take small organic / inorganic building bloc…
The fabrication of complex colloidal particles with anisotropic "patchy" e.g. Januslike, morphology will be studied. Known approaches towards "Janus particles" focus mostly on the micron-sized domain, with common fabrication routes based on monolayer modification or microfluidic…
Clay platelets and silica nanoparticles are used as Pickering stabilizers in the fabrication of hybrid armored polymer particles through a Pickering emulsion polymerization process. A variety of hydrophobic comonomers (i.e., styrene-co- (n-butyl acrylate) (Sty:BA), methyl methac…
Derivatives of enantiomerically pure 1,2-cyclohexanediamine and 1,2- diphenylethanediamine have been synthesised and used as organocatalysts for asymmetric reactions. The derivatives of 1,2-diphenylethanediamine have been employed for C-C, C-N bond formation reactions to determi…
By asymmetric transfer hydrogenation, substituted quinolines, which are generally regarded as challenging substrates for reduction, were successfully converted into tetrahydroquinolines using "tethered" Ru(II) and "tethered" Rh(III) complexes in formic acid/triethylamine. An eth…
A novel tandem process has been developed for the stereoselective synthesis of bicyclic γ-lactams. Treatment of an allylic alcohol with trichloroacetonitrile, in the presence of DBU, affords the corresponding allylic trichloroacetimidate. This is then subjected to a tandem Overm…
In many natural products, heterocycles, such as cyclic ethers, are important features. While there are many different approaches to the formation of these ethers, there are only a few methods available for the synthesis of substituted cyclic ethers with good diastereoselectivity…
Amphidinolides T are challenging natural targets for the total synthesis community because of their unique structural architecture. This thesis describes the investigations of the establishment of a novel and convenient route to synthesise four members of the natural product fam…
Nakadomarin A is a polycyclic marine alkaloid of the manzamine family. It was first isolated from the marine sponge Haliclona sp. collected off Manzamo, (Okinawa, Japan) and was characterised by Kobayashi and co-workers in 1997. The structure of this unprecedented compound was e…