Abstract In the UK, up to six million tonnes of potatoes are produced annually and more than half of this production is stored for the fresh market and food processing. To maintain potato quality from sprouting, chlorpropham (CIPC) is currently used as the main sprout suppressan…
"562" Result
Sort By:
This research examined the impact which onshore windfarms sited on peat-based soils have on streamwater carbon (C), phosphorus (P) and nitrogen (N) dynamics. Significant disturbance to peatland arises through the excavation of borrow pits, construction of access tracks, insertio…
A series of materials have been compared for their activity in the base catalysed condensation of acetone. Activities have been compared after extended times on stream (18 h) and under a H2 containing atmosphere at elevated pressure which is designed to mimic conditions applicab…
New general methodology for the stereoselective synthesis of unnatural alpha-amino acids has been developed. Early work focussed on investigating methods for the generation of chiral allylic alcohols using cross-metathesis of a simple enone with various terminal alkenes, followe…
Cryospray (CSI-) and electrospray mass spectrometry (ESI-MS) techniques have been utilised to investigate the key features of the ‘in-solution’, self-assembly processes by which complex polyoxometalate systems, such as ((n-C4H9)4N)2n(Ag2Mo8O26)n and ((n- C4H9)4N)3[MnMo6O18((OCH2…
Living systems exert exquisite control over biomineral production determining mineral type, polymorph, morphology and ultrastructure and ultimately producing biomineral structures that perform a range of functions. In addition to this biological control, the environment also inf…
Conjugated microporous polymers (CMPs) are a class of amorphous materials with pore sizes in the micropore range (< 2 nm). CMPs have potential advantages over inorganic and inorganic hybrid materials due to the use of only the lighter elements in the periodic table and their sta…
Manganese peroxidase 3 (MnP3) is an extracellular peroxidase from the white-rot fungus, P. radiata that is a well-studied wood/lignin degrader from Scandinavian forest (Hilden et al., 2005). Unlike the Phanerochaete chrysosporium MnP's previously characterised, the P. radiata Mn…
The sensory hair bundles of the cochlea are complex structures that are vital for hearing. Phosphorylation plays an important role in regulating actin in many cell types, but the role it plays in regulating the development and maintenance of the hair bundle has yet to be fully e…
One of a synthetic organic chemists‟ greatest challenges is to create step-efficient routes toward compounds with high molecular complexity. Therefore, reactions such as the meta photocycloaddition of an olefin to a benzene derivative, which provide more than one bond in a singl…
DNA damage is chronic, inevitable and extensive. Damage caused by UV irradiation can cause bulky DNA lesions that block replication forks. Postreplication repair (PRR) is a DNA damage tolerance mechanism, which enables the replication machinery to bypass DNA lesions. The PRR mac…
A [5:5] ligand based on the bicyclic guanidine 1,4,6-triazabicyclo[3.3.0]oct-4-ene [Htbo] has been synthesised. Two of these tbo units have been linked via a carbon bridgehead to form a novel bidentate ligand. Based on the knowledge that the electronic properties and specific st…
Influenza virus infection and the shikimic acid pathway are two of many examples of microbe-host interactions and microbial biosynthetic pathways that are interesting for investigation by means of small molecules. A particularly interesting structural motif common to both is the…
Matrix assisted laser desorption/ionisation mass spectrometry (MALDI-MS) is a relatively new technique for imaging lipids directly in tissue, with useful applications in disease state profiling, bacterial typing and forensics. This thesis describes optimisation and evaluation of…
The ‘Silicic Acid Leakage Hypothesis’ (SALH) is a mechanism by which the increased supply of silicic acid to the low latitude ocean allows diatoms (silica producers) to outcompete coccolithophorids (carbonate producers). This would result in a decrease in the export of carbonate…
Salt diapirs are some of the most dynamic geological structures in sedimentary basins and vertical rise through their overburdens leads to the development of complex fault systems. Polygonal fault systems constitute a major structural element of fine-grained sediments in sedimen…
In this investigation, cyclic voltammetry (CV), X-ray photoelectron spectroscopy (XPS) and rotating disc electrode (RDE) measurements of the oxygen reduction reaction (ORR) have been used to explore the complex three-phase Nafion-platinum-electrolyte interface. This interface is…
Small molecules, such as oligopeptides can interact with nucleic acid targets and subsequently stimulate or supress biological functions. The purpose of this thesis was to produce nucleic acid targeting oligopeptides which contain non-natural amino acids as part of their sequenc…
This thesis presents the design, synthesis and physical studies of new structurally-varied cationic oligoheteroaromatic DNA binders in six chapters. Chapter 1 introduces DNA and its importance in modern science such as genetic and medicinal research. The interactions of DNA with…