The physical properties and reactivity of 2,3-dihydro-1H-imidazo[1,2-f]phenanthridinium cations (DIPs) and analogous heterocycles have been investigated. The adapted syntheses developed were applied to a range of aryl amines and more elaborate substrates, such as bifunctional am…
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The synthesis and characterisation of sixteen new complexes are reported. The use of the ligand edte (((HOCH2CH2)2NCH2CH2N(CH2CH2OH)2)), H4L1) has resulted in five new iron complexes. Two Fe6 complexes and an Fe3 complex display non-zero ground states of S = 5 and S = 3 respecti…
Schafarzikite, FeSb\(_2\)O\(_4\), is a tetragonal mineral (space group P4\(_2\)/mbc) belonging to a family of compounds with the general formula MX\(_2\)O\(_4\). Schafarzikite has successfully been synthesised and chemically modified in various different ways. Lead has been subs…
An understanding of the crystal structure can aid in the rationalisation of physicochemical properties exhibited by a crystalline material. Advances in the area of direct space crystal structure solution means that it is becoming easier to determine crystal structures from powde…
The size of the prenylated indole alkaloid family sharing the unique bicyclo[2.2.2]diazaoctane core ring system has grown steadily over the last decades. Due to the complex structures, and in some cases the potent biological activity, these molecules have been adopted as challen…
Dry Reforming of methane (DRM) was performed successfully over hydrotalcite catalysts (A) Ni\(^2\)\(^+\)/Mg\(^2\)\(^+\)/Al\(^3\)\(^+\), (B) Ni\(^2\)\(^+\)/Mg\(^2\)\(^+\)/Al\(^3\)\(^+\)/Fe\(^3\)\(^+\), (C) Ni\(^2\)\(^+\)/Co\(^2\)\(^+\)/Al\(^3\)\(^+\) and (D) Ni\(^2\)\(^+\)/Co\(^2…
With an increasing academic and industrial interest in complex, multiphase fluids, there is an associated interest in obtaining suitable methods for simultaneous characterisation of structure and rheology of such systems under flow. In the present work, development and evaluatio…
Miniaturisation of devices and components is becoming increasingly important in the field of molecular devices. The design of multicomponent supramolecular systems that undergo photoinduced energy or electron transfer processes has been well recognised in view of its potential f…
PtIV-diazidodihydroxido complexes are inert in the dark, but can be selectively activated by irradiation with light and become potently cytotoxic towards cancer cells. By site-specific irradiation to tumour tissue, the side-effects to healthy tissue associated with conventional …
The interest in the development of anticancer metal complexes for cancer therapy is growing spurred by the encouraging successful stories of platinum drugs. Osmium arene chlorido complexes had been found to show anticancer activity in vitro. In this thesis, the osmium arene iodi…
The synthesis and characterisation of functionalised polyazamacrocycles and their subsequent immobilisation into porous materials were investigated and reported in this thesis. The incorporation of polyazamacrocycles into porous materials offers the potential to enhance their bi…
The asymmetric construction of substituted carbonyl compounds, particularly those containing α-quaternary carbon stereogenic centres, remains a significant area of interest in organic chemistry. This can largely be attributed to the ubiquity and versatility of these compounds as…
The objective of this thesis was to develop and prepare multifunctional magnetic nanoparticles with targeting and bimodal imaging capabilities for cancer diagnostic applications. Superparamagnetic iron oxide nanoparticles (SPIONs) were the key component in the multifunctional na…
Advances in modern science require the development of more robust and improved systems for electroseparations in chromatography. In response, the progress of a new analytical platform is discussed. DFGF (Dynamic Field Gradient Focusing) is a separation technique, first described…
Contour curvature information has been shown to have an impact on the visual perception of shape. We have conducted studies on perception of convexity and concavity in relation to memory and attention. Previous studies (Badcock & Westheirner, 1985; Krose & Julesz, 1989; Nakayama…
The asbestinins are a sub-class of the ether bridged 2,11-cyclised cembranoid family of marine natural products that have been isolated from octocoral species Briareum Asbestinum. They exhibit high structural complexity and a diverse range of bioactivities that include cytotoxic…
In the field of bone replacement therapy, biomaterials capable of acting in a scaffolding capacity are under constant review and improvement. To operate as a scaffold material, several requirements must be met. Initially, materials must exhibit mechanical properties similar to n…
Synthetic targets that mimic key structural and conformational features in proteins are of intense scientific interest. These structures can reproduce the biological activity of their naturally occurring counterparts, while improving their properties in vivo. This project focuse…
The kinesins are a class of microtubule based motor proteins which have extensive involvement in the orchestration of the mechanics of mitosis. The most studied of these is the kinesin spindle protein Eg5, which is crucially involved in the establishment of the bipolar spindle i…