(6S)-6-Fluoroshikimic acid 1 was developed as a potential antimicrobial which was converted to 6-fluorochorismate 2 and hence targeted the post-chorismate pathway to p-aminobenzoic acid 2 and folic acid (fig. 1). Although successful against microbial challenge, resistance develo…
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The number of protein structures deposited in the Protein data bank is increasing almost exponentially and among these structures many of the proteins are novel with unknown function. Like Docking, Pharmacophore searching is an In-silico technique which is widely used for drug d…
Trafficking of the facilitative glucose transporter GLUT4 is regulated by insulin in fat and muscle cells. Under basal conditions, GLUT4 is retained intracellularly by continually cycling through the endosomal system, but translocates to the plasma membrane in response to insuli…
There is an urgent need for new chemotherapies against human African trypanosomiasis (HAT), caused by the protozoan parasite Trypanosoma brucei. It is anticipated that the parasites’ divergent biochemistry will enable development of novel therapies. To study the behaviour of a c…
The life cycle of Schistocephalus solidus had been known for over thirty years but there was little information in the literature on the maintenance of the life cycle in the laboratory. It was thus decided to obtain each stage of the life cycle under laboratory conditions and st…
Mammalian and fission yeast cells determine the site of division by the medial placement of an actomyosin contractile ring. Contraction of this ring then leads to cytokinesis and the final separation of the equal-size daughter cells. In the fission yeast Schizosaccharomyces pomb…
Cyclic adenosine monophosphate (cAMP) is a second messenger signalling molecule that has been reported to exert beneficial effects within the vasculature and other physiological systems. cAMP produces its effects within the cell through two key downstream effector molecules: exc…