Nephrops norvegicus is a mid-sized benthic decapod lobster found at depths of between 30-300 metres along the eastern Atlantic coast from Norway to Morocco, and within the Mediterranean sea. They inhabit marine muddy sediments in which they excavate burrow systems and from which…
"242" Result
Sort By:
The aim of this research was to investigate the blood supply to the lower abdomen. This is a commonly used donor site for autologous reconstruction following breast cancer and the flap of tissue used is based on the deep inferior epigastric circulation (DIEP flap) or the superfi…
In this thesis, a method for studying the electrophysiological consequences of acute regional ischaemia in rabbit heart was established using a combination of a novel snare technique and optical mapping. The purpose of this approach was to discover the mechanistic link between a…
Therapeutic antibodies are highly versatile macromolecules that can be engineered to bind and inhibit a target with high specificity. Unfortunately, the cell membrane is impenetrable to antibody reagents, thus limiting their use almost entirely to extracellular targets. Expandin…
The CaBPs are a family of small EF-hand-containing calcium binding proteins with limited homology to calmodulin (CaM). The family comprises seven genes with alternative splicing giving rise to a greater number of protein variants. Two distinct groups exist within the CaBP family…
Adverse drug reactions (ADRs) are a major obstacle for the development of new medicines. They are also a leading cause of patient morbidity and mortality. Although ADRs affect many different organs and bodily systems, drug induced liver injury has lead to the withdrawal of sever…
The control of balance and orientation comprises various forms of sensory input, reflexive action and anticipatory mechanisms. An important sensory input is the vestibular system. When a destabilising or disorientating perturbation is sensed by the vestibular apparatus a correct…
Aims: To fully characterise the RGC-5 cell line and determine whether it would be a suitable substitute for primary RGC cell culture. To optimise a CNTF Nogo-P4 inhibitory assay and establish whether (a) CNTF alone is capable of stimulating RGC neurite outgrowth and survival, or…
The mammalian target of rapamycin (mTOR), which controls diverse cellular processes, is regulated by the integration of many signals. Rapamycin strongly inhibits the proliferation of many cancer cell lines and there is a high level of interest in its potential use as an anti-can…
Background: Exercise may acutely and chronically up-regulate appetite and energy intake in overweight and obese women preventing body mass reduction in the long term. Overweight and obese women may be most prone to compensatory responses to exercise but the possible mechanism fo…
In Scotland, stroke is the third most common cause of death behind heart disease and cancer. However, most strokes are not fatal and can cause severe disability, with one third of survivors still functionally dependent after one year. The advent of recombinant tissue plasminogen…
Colonic inflammation in C. difficile infection is mediated by released toxins A and B. I have investigated responses to C. difficile toxin A and B by primary human colonic myofibroblasts, which represent a distinct subpopulation of mucosal cells that are normally located below t…
The natural angiogenic response of the vasculature to cardiovascular disease has been shown, at least in part, to involve circulating endothelial progenitor cells (EPCs). However, the native response is often insufficient to restore vascularity without additional intervention. I…
The force response of the locust hind leg extensor muscle to input excitation pulses is modelled. Despite the processes behind muscle contraction being well established, no broadly valid method of modelling skeletal muscle exists. Studies that compare the merits of existing mode…
A common consequence of the complications of pregnancy, such as preeclampsia, is reduced supply of nutrients, including oxygen, to the developing fetus. The consequences for the offspring are wide ranging, but include increased risk of cardiovascular disease. However, the mechan…
Factors contributing towards falls in older age during overground walking have been widely studied. Stepping behaviour, balance and head posture control during stair negotiation in young adults (YA) and older adults with either lower (LROA) or higher (HROA) risk of falling durin…
The primary purpose of this thesis is to present a comprehensive analysis of occupant kinematics and spinal injuries, during road traffic accidents in Saudi Arabia from the points of view of statistical analysis, modeling of occupant kinematics, and biomechanics. An in-depth dat…
Symptoms of gastro-oesophageal reflux disease are equally common in both sexes and at all ages. However, complications of gastro-oesophageal reflux disease such as reflux oesophagitis, Barrett's oesophagus and oesophageal adenocarcinoma, although more common in men, increase sha…
Tendon and ligament damage causes extreme pain and decreased joint functionality. Current repair methods cannot restore original joint biomechanics nor promote regeneration of native tissue. Recent advances in tendon and ligament repair have involved engineering tissue using cel…