Background: Osteoarthritis affects approximately 40% of older adults but molecular mediation of OA pain in the dorsal horn is unexplored clinically. This study explored amino acids and cytokines related to pain signalling and sensitisation to determine whether significant differ…
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With the advent of facial transplantation some academic authors have suggested that faces are significant for humans and that identities are located corporeally within faces and therefore transplantable. However, there has been little evidence to support these claims, particular…
Serotonin (5-HT) is a neurotransmitter that is mainly expressed in brain where serves a wide array of physiological and behavioural functions. Literature described that some mediators of inflammation (i.e. cytokines) have been implicated in the modulation of monoaminergic respon…
The aim of this thesis was to investigate the impact of the Managed Clinical Network (MCN) for colorectal cancer in the West of Scotland on outcomes for its patients. The alternative hypothesis was that greater changes to patient outcome had occurred over time than those that wo…
Background: The present study aimed to explore if risk factors associated with loading at knee were associated with degenerative changes in ACL injured groups. Methods: Part 1: Biomechanics were investigated for gait, jogging and single legged squatting (SLS) in Anterior Crucita…
Researchers have indicated the need for consideration of emotional distress prior to surgery. Measures of pre-operative anxiety have been developed and include the Pre-operative Intrusive Thoughts Inventory (PITI). The aim of the present study is to evaluate the application of t…
If the intrinsic control of the liver is responsible for these changes it would be important to show that the liver is more metabolic as the changes occur. An intervention to lower the metabolic demand on the liver is difficult and may not be ethical given that the normal respon…
Carotid endarterectomy has been demonstrated to reduce future stroke risk; however, stroke is a procedural risk. Therefore, to achieve the maximum benefit for patients, complications must be minimised. There are variations in the way that the operation is performed which may inf…
Background: Oral squamous cell carcinoma (OSCC) is the 15th most common cancer worldwide but has poor five year survival (50%). Late stage presentation and limitations of early diagnostic techniques are persistent clinical problems. Sixty percent of patients present with advance…
Kidney Transplantation is the gold standard treatment for patients with end-stage renal failure. Most kidneys used for transplantation are from deceased donors and ensuring successful outcomes depends on many factors. One of these is organ storage. Hypothermic Machine Perfusion …
Donor organ shortage is a major barrier to the progress of liver transplantation; options to widen the donor pool include use of marginal donor grafts and those from donors after circulatory death (DCD), despite risks of early graft failure. This thesis studies the key metabolic…
Postoperative pain is still poorly managed among surgical patients despite evidence-based approaches to its treatment being well established. Prompted by the persistence of this problem, many researchers have studied factors influencing postoperative pain management. Empirical c…
The selection for specific physical characteristics by dog breeders has resulted in the expression of undesirable phenotypes, either directly or indirectly related to the physical characteristic selected for. One conformation that was considered desirable is extreme brachycephal…
The aim of this research was to investigate the blood supply to the lower abdomen. This is a commonly used donor site for autologous reconstruction following breast cancer and the flap of tissue used is based on the deep inferior epigastric circulation (DIEP flap) or the superfi…
Major vascular surgery is associated with a substantial risk of cardiovascular events and death. This risk is of increased importance in prophylactic elective open Abdominal Aortic Aneurysm (AAA) repair, where a balance of risk of rupture and postoperative outcome is assessed pr…
The thesis reviews the literature regarding the relationship between the local and systemic inflammatory responses and outcome in patients with gastro-oesophageal cancer. The study chapters then examine the relationship between the systemic inflammatory response and survival, in…
Introduction: 12,000 infrainguinal bypass grafts are performed annually in the UK. Despite improvements in surgical technique, outcomes remain suboptimal: 20% of above knee grafts require intervention to maintain patency by 3 years. Only antiplatelet agents have been demonstrate…
Despite the scientific, technological and surgical improvements of the past 50 years organ dysfunction following elective paediatric cardiac surgery utilising cardiopulmonary bypass continues to account for increased complications, often leading to a protracted course in hospita…
Introduction: In the past five years chronic post herniorrhaphy pain has become the predominant post operative complication following the common procedure of inguinal hernia repair. However information regarding the precise aetiological factors of this chronic post surgical pain…