At a time when health literacy is emerging as a central concern in the health field, this thesis examines whether and how practitioners involved in the promotion of breastfeeding incorporate dimensions of health literacy as described in the current literature. Although there is …
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INTRODUCTION Brain tumours are the most common solid tumour in childhood, while Magnetic Resonance Spectroscopy (MRS) studies have been performed on brain tumours previously, the majority have been performed on the adult patient population and at long echo times. The work presen…
Arthrogryposis, Renal dysfunction, and Cholestasis (ARC) syndrome is a multisystem disorder associated with abnormal localisation of some polarised membrane transporter proteins. Distinct apical and basolateral poles are essential for epithelial function and organ development bu…
Objectives - To develop and pilot a community-based family programme, ‘Families for Health’, for intervention with overweight and obese children aged 7-11 years. Intervention – ‘Families for Health’ is a 12-week programme, with parallel groups for parents and children, combining…
Biliary atresia is a common form of paediatric liver disease, with progressive, inflammatory obliteration of the biliary tree, leading to liver failure early in life. Mutations in PKHD1, encoding the ciliary protein fibrocystin, are associated with autosomal recessive polycystic…
Development of the human brain occurs in a number of complex pre- and postnatal stages which are governed by both genetic and environmental factors. Aberrant brain development due to inherited defects may result in a wide spectrum of neurological disorders which are commonly enc…
Background: The onset of Inflammatory Bowel Disease (IBD) is highest during adolescence. The symptoms may make the essential developmental transitions associated with this stage more challenging and cause difficulties in psychosocial functioning. While previous research has comp…
Vaccination is regarded by the medical profession as one of the greatest public health success stories, and recent opposition, for example over the MMR (measles, mumps and rubella) vaccine, as a failure of understanding. Relatively little social scientific analysis exists on vac…
This thesis reports a series of laboratory and clinical studies designed to investigate the acute effect of surgical palliation on ventricular function in children with functionally single ventricle anatomy. Ventricular volume and pressure were measured using a combined pressure…
Liver disease in children is rare but often serious, life long, and in many cases leads to death. Advances in diagnosing and treating liver disease (including liver transplant) have improved the outlook for children in many cases however little is known about the molecular patho…
Source analysis of the Auditory Evoked Potential (AEP) has been used before to evaluate the maturation of the auditory system in both adult and children; in the same way, this technique could be applied to ongoing EEG recordings, in response to acoustic specific frequency stimul…
In the absence of readily available physiological models of human growth, the effects of oestradiol on the human C28/I2 chondrocyte cell line were studied. The classical oestrogen receptors, ERα and ERβ, were shown to be expressed in both murine and human chondrocyte cell lines.…
Existing research indicates that typically developing children pass through predictable stages of fear development throughout their childhood. Evidence suggests that in general, children with disabilities experience more fears than typically developing children. Children with di…
Paper partition chromatography has been used extensively to study the aminoacid excretion in the urine of healthy children, of newborn infants and of patients suffering from eight different metabolic disorders. The purpose of this investigation was to discover the aminoacid patt…
Introduction: The development and application of next generation sequencing (NGS) technology has led to an exponential rise in the number of genes and genetic variants associated with epilepsy. The detection of highly penetrant and damaging variants in some patients can be suffi…
There is significant current attention towards the possible impact of social media on adolescent wellbeing, with concerns voiced by parents, educators, practitioners and national policymakers. This includes a focus on social media's influence on sleep, which plays a crucial role…
Aims: Since 2008, in England, all sudden unexpected deaths in infancy (SUDI) must be investigated jointly by police, health and social care. This thesis aims to learn of parents’ and professionals’ experiences of this joint agency approach (JAA) and use this knowledge to improve…
While it is widely acknowledged that all family members have a role to play in raising a child with Intellectual Disability (ID), research in the field has focused on the wellbeing of mothers and mother-child relationships. Working within a Family Systems theoretical framework, …
Social, emotional and behavioural aspects of development are key to children’s overall development. A failure to develop normally in any one of these areas can have far reaching consequences, affecting the child’s ability to learn and to develop relationships with peers, potenti…