The objective of this study was to examine effects of ultrasound on a disuse bone model and osteoblast cell cultures in simulated microgravity. This will help us understand the effects of ultrasound on microgravity induced osteoporosis and provide a non-invasive and more targete…
"14" Result
Sort By:
Lysophosphatidic acid (LPA) is known to exert a diverse range of effects in humans, specifically in the heart where it may cause apoptosis of cardiomyocytes at pathological concentrations. However, at physiological concentrations LPA may regulate cell migration, proliferation an…
MicroRNAs play an important role in biological regulation. Recently miR-34a has been reported to regulate tumour cell cycle progression and apoptosis. However, the functional role of miR-34a in smooth muscle cell (SMC) differentiation from stem cells is yet unclear. Main objecti…
A previous study in this laboratory found that hard red wheat is more effective than soft white wheat in reducing colon cancer risk, regardless of processing state, based on fewer aberrant crypt foci (ACF), a morphological marker of colon cancer risk. Here we examined the effect…
The realization of many potential cell therapies will depend on the development of culture protocols that consistently expand stem and progenitor cell numbers while retaining their developmental properties. Hematopoietic cell lines were used to develop predictive mathematical mo…
Ever since the earliest cavemen was mauled by a mammoth, stabbed by a flint-headed spear or burned by a stone age cooking fire, men and women have fought to heal wounds. We have records of wound care that trace back to ancient Egypt and Greece, circa 1500 BC. Today, patients and…
Our understanding of Alzheimer’s disease (AD) pathogenesis is currently limited by difficulties in obtaining live neurons from patients and the inability to model the sporadic form of AD. It may be possible to overcome these challenges by reprogramming primary cells from patient…
Transcription factor forkhead box N4(Foxn4) is a key regulator involved in a variety of biologic processes in development and metabolism. In particular, Foxn4 plays an essential role in the genesis of amacrine and horizontal neurons from neural progenitors in the retina. Althoug…
Chapter 1 introduces the main research question to be answered: when does personhood begin? The chapter outlines the context of the debate, explains the importance of this issue and its relevance to Christian life, and presents the thesis and methodology of this dissertation.
Delineating a cell’s history, where it came from and what has happened to it, can provide clues as to how tissues and organs are formed and function in the healthy state and in disease. The gold standard for tracing the relationships between cells and their progeny, is performed…
IntroducaoA transfusão dos eritrócitos é a base para o tratamento de doentes com hematopoiese comprometida e para doentes com perdas significativas de sangue. Após a transfusão de eritrócitos, existe contacto com antigénios, nomeadamente, estruturas de polissacarídeos e proteína…
The niche in which stem cells reside is involved in the regulation of stem cell fate, such as differentiation and self-renewal, by providing ECM proteins, growth factors, cell-cell interactions and balancing chemical factors such as the level of oxygen and pH. ECM proteins are i…