synthesis

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Providing graduate and advanced undergraduate students with an introduction to the chemistry of macromolecular substances, this book includes their synthesis and the properties underlying their commercial importance. It also covers developments in polymer science and the methods…

An approach toward the synthesis of FK-506 is described. The strategy is convergent, and disconnects the macrocycle into four manageable subunits; phosphonate 85, aldehyde 86, bromide 87 and aldehyde 88. An efficient synthesis of aldehyde 86 and its elaboration to bromide 83 is …