Approximately 1 in 1000 children are born with congenital cardiovascular defects yearly in the US, including many abnormalities in heart valves. Tissue engineered heart valves (TEHVs) offer a solution for replacement or repair of affected valves. However, its therapeutic applica…
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Development of small-diameter blood vessels using tissue engineering has been promising as a novel therapy for patients who require coronary artery bypass grafting but lack suitable donor tissue. However, the performance of tissue engineered vascular grafts (TEVGs) has been chal…
Morphology, cytoskeleton organisation and nuclear states are important biomarkers to characterise and modulate cell behaviours. Bilateral interactions between cells and their surroundings are critical aspects of biology, evidenced by the role of extracellular environment mechani…
Unlike thin tissues (e.g., skin) which has been successfully grown, growing thick tissues (e.g., bone and muscle) still exhibit certain limitations due to lack of nutrients (e.g., glucose and oxygen) feeding on cells in extracapillary space (ECS) region, or also known as scaffol…
Mechanical stimulation, in combination with biochemical factors, is likely to be essential to the appropriate function of stem cells and the development of tissue engineered constructs for orthopaedic and other uses. A multi-axial bioreactor was designed and built by Bose Electr…
A promising approach to overcome thrombus and neointima formation on vascular grafts is to create a functional, quiescent monolayer of endothelial cells on the surface of implants. Surface topography of these implants is proven to enhance cell attachment and to reduce the inflam…
The aim of this project was to create a novel biodegradable, synthetic scaffold that will provide the correct topographical cues for myoblast alignment and efficient differentiation into myotubes. Skeletal muscle repair after major surgery or serious burns is often overlooked le…
Ever since the earliest cavemen was mauled by a mammoth, stabbed by a flint-headed spear or burned by a stone age cooking fire, men and women have fought to heal wounds. We have records of wound care that trace back to ancient Egypt and Greece, circa 1500 BC. Today, patients and…
Günümüzün en yaygın sağlık problemlerinden biri doku kaybı, yaralanması ve zedelenmesidir. Birçok hasta uygun doku nakli için beklemektedir. Aynı hastadan doku alıp yine o hastaya emplante etmek veya ölü bir canlıdan doku alıp hastaya emplante etmenin ekonomik olmaması, bağışçı …
Günümüzde, doğal polimerler, sentetik petrol bazlı polimerlerin çevre dostu olmayan özellikleri nedeniyle endüstri için trend hammaddeler haline gelmiştir. Doğal, parçalanabilir polimerlerin kullanılması yıllar içinde artmıştır ve bu ihtiyacı karşılamak amacıyla birçok doğal pol…
Jelatin – metakrilamid hidrojellerin doğal polimerler ile 3 boyutlu yazıcılar kullanılarak üretilen yumuşak doku uygulamaları, deri rejenerasyonu açısından büyük potansiyel taşımaktadır. Bu tez çalışmasında, doku yapılarını taklit eden yapay bir yapı oluşturmak için jelatin ile …
The seeding of a porous scaffold with stem cells is a fundamental step in engineering sizeable tissue constructs that are clinically viable. However, a key problem often encountered is inhomogeneous seeding of the cells particularly when the cells are delivered through the thick…
Recent research has demonstrated a strong correlation between the differentiation profile of mesenchymal stem cells (MSCs) and scaffold stiffness. Chitosan is being widely studied for tissue engineering applications due to its biocompatibility and biodegradability. However, its …
Proper cell-cell communication through physical contact is crucial for a range of fundamental biological processes including, cell proliferation, migration, differentiation, and apoptosis and for the correct function of organs and other multi-cellular tissues. The spatial and te…