The hydrogen permeability of surface modified Pd\(_6\)\(_0\) Cu\(_4\)\(_0\) wt% (Pd\(_4\)\(_7\)\(.\)\(_3\)Cu\(_5\)\(_2\)\(_.\)\(_7\)at%) membranes have been determined for the first time. Surface modification was accomplished through the deposition of Pd thin films of three diff…
Dry powder inhalers (DPIs) are widely used for the therapy of respiratory and pulmonary diseases. In this study, a coupled discrete element method and computational fluid dynamics (DEM-CFD) is employed to investigate the micromechanics of carrier-based DPIs. The effects of van d…
There is an increasing demand from the pharmaceutical and food industries for new probiotic products. Some yeast strains offer probiotic benefits, but it has not been possible to formulate them successfully into a tablet dosage form. Direct compression is regarded as the best te…
Vapour – liquid equilibria were measured for the acetic acid + water and the propanoic acid + water systems, in the temperature range of 412.6 to 483.2 K and pressures of 1.87 to 19.38 bar, over the entire range of concentrations. An experimental apparatus based on the static-an…
Calcination, is the process of heating a substance, to a temperature below its fusing point, with a resultant loss of water. It is one of the most important techniques currently used to enhance the properties, and therefore value, of kaolin. The overall aim of this project was t…
There is huge need to develop an alternative to hydrocarbons fuel, which does not produce CO2 or contribute to global warming - 'the hydrogen economy' is such an alternative, however the storage of hydrogen is the key technical barrier that must be overcome. The potential of gra…
This thesis describes the research and development into a range of time-temperature integrators (TTIs) for the measurement of process values for food heat treatments. The TTIs are based on the first order thermal degradation of bacterial \(α\)-amylases. Two new TTIs are describe…
The practical feasibility and generic applicability of the direct integration in the same time frame of cell disruption by bead milling with the capture of intracellular products by fluidised bed adsorption has been demonstrated. Pilot-scale purification of the enzyme L-asparagi…
Freeze-drying is an energy demanding operation involving dehydration through sublimation of ice crystals. It has important application in the production of high quality dried food such as instant coffee. Correlating the operating conditions with product attributes is essential t…
In this research work, the effect caused by electrical processing on mass transfer in food materials was studied by designing and performing experiments that allowed the visualisation of: the effect of moderate electrical fields (MEF \(\leq\)1000V cm\(^{-1}\)) on mass transfer i…
High demand of Liquefied Natural Gas (LNG) in recent time requires LNG carriers in more frequent operations in order to meet customers' needs. To ensure that the LNG carriers are always reliable in service, it has become necessary to adopt various advanced modelling techniques s…
The research presented in this thesis explores the design and fabrication of microstructured and switchable biological surfaces, which may have potential applications of nanobiotechnology. The thesis focuses on the fabrication of biological surfaces which can be controlled via e…
Mechanical properties of the plant cell wall are important in many industrial applications including biofuels, food quality and biotechnology. The plant cell wall consists of a network of cellulose microfibrils cross-linked with hemi-cellulose and interpenetrated by pectin. It i…
In the light of the recent research interest in emulsion formation, this PhD thesis seeks to expand the current body of knowledge regarding the role of various emulsifiers on emulsion formation mechanisms. This study is particularly relevant to the food industries, where formula…
An experimental study was carried out concerning the optimization of catalyst type, operating conditions, addition of water and hydrogen for use in the THAI-CAPRI process and is reported. Three feeds namely, THAI field oil, Combustion Cell Oil (CCO) and n-decane were used in the…
One of the major drawbacks to the large scale application of magnetic support based separations in biotechnology is the astronomic price of large quantities of commercially available magnetic support materials. The aim of this work has been to develop a simple, fast and scalable…
Gelation of hydrocolloids under shear conditions results in a weak gel which is capable of sustaining elastic mechanical deformation at small strains but which flows if subjected to higher deformations (fluid gels). I have investigated the formation, production and lubrication p…
The thesis starts with characterization of alginate that involved the viscosity, ageing, and degradation of different concentrations of alginate. Live/Dead, MTT, and Hoechst 33258 assays were used to investigate cell viability and proliferation in alginate discs. Pulsed-low inte…
Tendon and ligament damage causes extreme pain and decreased joint functionality. Current repair methods cannot restore original joint biomechanics nor promote regeneration of native tissue. Recent advances in tendon and ligament repair have involved engineering tissue using cel…