Vibrio cholerae

NQR is a six-subunit complex that transfers electrons from NADH to ubiquinone, one of the essential enzymes in the bacterial respiratory chain of many pathogens such as Vibrio cholerae, Pseudomonas aeruginosa, Chlamydia trachomatis. Its electron transfer path requires three diff…

Several Vibrio species are bioluminescent, including Vibrio cholerae. Analysis of 224 non-pathogenic V. cholerae isolates collected from the Chesapeake Bay, MD, revealed that 52% were luminescent, and 58% of the isolates harbor the luxA gene. A significant association of luxA to…

Consisting of four articles, this thesis focuses on using time series analyses and theoretical modeling approaches to understand cholera dynamics and evolution in endemic regions. The first article develops a nonlinear statistical model with two related objectives: the reconstru…

Vibrio cholerae O1 El Tor and O139 Bengal have caused cholera epidemics throughout Bangladesh and elsewhere in the world with a seasonal regularity. This has raised questions about whether clinical presentations of cholera caused by these two epidemic serogroups of V. cholerae r…

The World Health Organization (WHO) states that 30,000 children under the age of five die each day worldwide. Around a quarter of these die from diarrheal disease caused by microbial infection. In addition to this high mortality rate, there are data emerging on the morbidity eff…

The spread of cholera is always associated with contaminated food or water and this is the reason this disease has been endemic in developing countries for centuries due to their lack of proper sanitation facilities and poor or no infrastructure for sewage systems. Cholera can s…