Excessive neutrophilic inflammation of the airways in response to infection is characteristic for patients with CF. There is also an important but not fully understood role for platelets. Previous studies established increased copper levels in the circulation and in the sputum i…
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Options for treating Burkholderia cepacia complex (Bcc) and other multi-resistant Gram negative bacilli isolated from people with cystic fibrosis (CF) are limited. We assessed the in-vitro activity of tigecycline and eleven other antimicrobial agents against a collection of thes…
Each year, NHS clinical laboratories carry out more than 700 million laboratory tests, of which 50 million are microbiology investigations. Several studies have shown that between 25% and 40% of all tests sent to the laboratory are unnecessary, and up to 46% of ordered microbiol…
Over the past forty years concerns over the presence of pharmaceuticals in the environment have grown considerably. Some pharmaceuticals can be effectively biodegraded in wastewater treatment plants but others can be sorbed onto sludges that are often subsequently used as fertil…
Duchenne muscular dystrophy (DMD) is a hereditary, X-linked, muscle wasting disease with no known cure. It is caused by altered mechanical stability of muscle cell membranes combined with altered cell signalling and inflammatory infiltrations due the absence of the cytoskeletal …
Aims The method for the confirmation of drugs of abuse for addiction testing within King’s College Hospital prior to 2008 was a labour intensive thin layer chromatography method. To replace this with a faster method more suited to future requirements, the laboratory bought a liq…
Towards the development of drug carriers that are capable of crossing the Blood Brain Barrier, the techniques of emulsion polymerisation and nanoprecipitation have been utilised to produce nanoparticulate carriers from a systematic series of alkylglyceryl dextrans (of two differ…
The spore forming bacterium, Bacillus anthracis is the aetiological agent of anthrax. The 2001 US anthrax letter attacks and the 2009‐2010 outbreak of injectional anthrax in the UK highlighted the importance of early detection and confirmation of this agent, both for patient out…
Boron neutron capture therapy (BNCT) is a method for selectively destroying malignant (normally glioma) cells whilst sparing normal tissue. Irradiation of 10B (large neutron capture cross-section) with thermal neutrons effects the nuclear fission reaction: 10B + 1n → → 7Li+ + α …
In order to monitor progression of COPD there is a need to develop indicators that accurately reflect observed symptoms. This information can then be used to inform treatment and also advice patients as to lifestyle changes that should be made to improve the outcome of the disea…
Duchenne muscular dystrophy (DMD) is the second most commonly inherited disorder in man, the phenotype of which displays pathological characteristics of altered skeletal muscle function including, amongst others, abnormal Ca2+ homeostasis and cell signaling. This study used the …
Aim: To establish whether Chinese Herbal Medicine (CHM) has any positive effect on human endometrial receptivity to embryo implantation. Design: A prospective interventional clinical study. The measurements used in this study were: serum follicle stimulating hormone (FSH), serum…
Background: The reported incidence of prostate cancer (PCa) has increased in recent years due to the aging of the population and increased testing; however mortality rates have remained largely unchanged. Studies have shown deficiencies in predicting patient outcome for both of …
Progress made in the palliation of those with terminal cancers has allowed most symptoms to be controlled if not completely alleviated. For many in this situation now, the most overwhelming and unpleasant ongoing problems are related to the accompanying cachexia. Cachexia - (Gre…
Infection with Coxiella burnetii in humans is associated with severe disease, known as Q fever. Acute infection, that can be sub-clinical in nature, can lead to the development of a chronic life-threatening cardiac condition. The largest reported human outbreak of Q fever recent…