This project investigated the development of novel anticancer agents with good efficacy and selectivity. Cryptolepine is an alkaloid found in the roots of West African climbing shrub species including Cryptolepis triangu- laris and Cryptolepis sanguinolenta. Cryptolepine is 5-me…
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Mycoplasmas are the smallest and simplest self-replicating prokaryotes, lacking a cell wall and are bound by a single membrane-the plasma membrane. Moreover, mycoplasmas are consequential and chronic pathogens of humans and animals that rely on adhesion to host tissue for coloni…
In western countries at least one third of the population develops cancer. The main cause of death in cancer patients is metastasis and there is no effective treatment for this complication. The situation can be improved by a better understanding of the cancer invasion process. …
Breast cancer is the most common malignancy among females. Although considerable progress in disease detection and treatment has greatly improved survival, this entails the endurance of sequential treatment combinations. Such treatments are associated with cancer related fatigue…
Most human cancers carry mutations in cell cycle regulators that result in deregulated Cdk activity, which can either be amplification of the cyclins, elimination of the Cdk inhibitors or mutations in the Cdks. These modifications have a high prognostic value. Cdk2 activity has …
Enzymes such as aromatase, 17[beta]-hydroxysteroid dehydrogenase [types 1 (17[beta]-HSD1) and 3 (17[beta]-HSD3)] and estrone sulfatase (ES) are all involved in the biosynthesis of steroids via the steroidal cascade. The inhibition of these enzymes may lead to a reduction in the …