Targeting CK2 for cancer therapy has proven effective in inhibiting tumor growth in several histology’s. The main goal of this study was to acquire pre-clinical data on a naturally occurring CK2-inhibitor (ellagic acid) in support of a human clinical trial. In vitro analysis inc…
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Accumulation of unfolded proteins induces endoplasmic reticulum (ER) stress. Excessive and prolonged periods of ER stress leads to apoptosis. In this work we investigated the involvement of Death Associated Protein 1 (DAP1) in ER stress cellular responses and the associated cell…