Thesiss

Modern design of controlled release delivery systems deviates from the use of standard polymeric materials available and concentrates on development of novel biopolymers. In this study, new synthetic linear and cross-linked ampholytic polyelectrolytes consisting of tertiary amin…

The feasibility of hot melt extrusion (HME) was explored for development of amorphous solid dispersion systems. Controlled release formulations were developed using a cellulose based derivative, AffinisolTMHPMC 100cP and 4M grades. BCS class II drugs ibuprofen and posaconazole w…

The aim of this thesis was to examine the ability of metal organic frameworks (MOFs) to store and controllably release biologically significant amounts of nitric oxide (NO). Initial work involved the synthesis of a series of isostructural MOFs, known as M-CPO-27, which display c…