Thesiss

Expression of the platelet-derived growth factor receptor (PDGFR) correlates with metastatic medulloblastoma and PDGF treatment of medulloblastoma cells activates the pro-survival and pro-migratory pathways downstream of the receptor, for instance, increases extra-cellular regul…

Malignant glioma have poor prognosis resulting mainly from high level of cell proliferation and invasion and resistance to conventional therapy. Identification of novel targets that are critical elements in gliomagenesis may help improve therapeutic outcome. Using genome-wide ex…