Cell adhesion to the extracellular matrix is mediated by the integrin family of adhesion receptors. Integrin receptor engagement initiates the formation of multimolecular protein complexes, termed integrin adhesion complexes (IACs), at the cell membrane. IACs are complex signall…
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The aim of this project was to create a novel biodegradable, synthetic scaffold that will provide the correct topographical cues for myoblast alignment and efficient differentiation into myotubes. Skeletal muscle repair after major surgery or serious burns is often overlooked le…
Andes virus (ANDV) causes a fatal hantavirus pulmonary syndrome (HPS) in humans and Syrian hamsters. Human avβ3 integrins are receptors for several pathogenic hantaviruses, and the function of avβ3 integrins on endothelial cells suggests a role for avβ3 in hantavirus directed va…
The niche in which stem cells reside is involved in the regulation of stem cell fate, such as differentiation and self-renewal, by providing ECM proteins, growth factors, cell-cell interactions and balancing chemical factors such as the level of oxygen and pH. ECM proteins are i…