Thesiss

Persistent Aurora (Aur) A and B over-expression, centrosome amplification (CA), chromosomal instability (CIN) and aneuploidy invariably occur together in a vast majority of human neoplasms. These molecular changes are frequently found (>80%) in human sporadic ductal carcinoma in…

Beyond genes, at different scales, cancer exhibits a narrow dialectic interaction with other cells and with its physical environment, undoubtedly an ecological phenomenon. This thesis focuses on theoretical, analytical, and experimental approaches at different scales; from cance…