Gram-negative bacteria have a variety of systems that catalyse the formation of disulphide bonds, which are essential for the folding, activity, and stability of many periplasmic and secreted proteins. The scsABCD (suppressor of copper sensitivity) locus of Salmonella enterica e…
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Iron oxide magnetic nanocomposites can be used for a variety of biomedical applications, including magnetic resonance imaging (MRI) and as site specific drug delivery systems. By functionalising the surface of the nanocomposite, other functions like cell labelling and targeting …
Optical coherence tomography (OCT) is a non-invasive, non-contact optical technique that allows cross-section imaging of biological tissues with high spatial resolution, high sensitivity and high dynamic range. Standard OCT uses a focused beam to illuminate a point on the target…
Bis(thiosemicarbazone) ligand derivatives and their metal complexes have long been of interest as they have applications as anticonvulsants, super-oxide dismutase-like radical scavengers, in the investigation of Alzheimer’s disease and diagnostic imaging. Copper (II) bis(thiosem…
Effects of gases (primarily N₂O₄, BF₃, O₂ and NH₃) on the electrical properties of molecular single crystals of donors (phthalocyanine and its Mn(II), Co(II), Ni(II), Cu(II), Zn(II) and Ph(II) complexes, anthracene, perylene and the bis(8-hydroxyquinoline) complexes of Cu(II) an…
Although the three-dimensional quadrupole ion trap has received some attention as a mass spectrometer, few reports have been published describing the more general exploitation of its ion storage capabilities« This latter aspect is the subject of the present research. Initially t…
Over the last 30 years there has been deep interest into the folding of proteins and the mechanisms in which they fold. One of the rate limiting steps of protein folding has been shown to be the cis/trans isomerisation of proline residues, which is catalysed by a range of peptid…
Genome organisation can be considered at a number of levels from the karyotype to gene order, copy number variation and the organisation of chromosome territories and loci within the interphase nucleus (nuclear organisation). Detailed studies of these areas in birds however are …
PET is a potent imaging technique that uses positron emitting radionuclides such as 18F, which is used either in the form of [18F]FDG or attached to another biomolecule for diagnosis of disease and monitoring of treatment. The major disadvantage of labelling molecules with 18F i…