Cytokinesis is the process in which two independent daughter cells are generated from one parent cell following mitosis. Completion of mitosis requires microtubule dependent transport of membranes to the midbody. The research presented in this thesis demonstrates a cytokinetic r…
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Chronic Myeloid Leukemia is characterised by the formation of a fusion gene bcr-abl. The gene product BCR-ABL has deregulated tyrosine kinase activity that plays a direct role in the pathogenesis of the disease. Recently, use of siRNA in leukaemic cells has led to effective gene…