Over the past two decades, drug delivery systems have become a subject of major interest in the pharmaceutical industry for the treatment of different diseases, such as cancer, viral infections, and genetic disorders. A wide range of compounds show high binding affinity and grea…
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Hydrogen bond mediated self-assembling carbamates with alkyl side chains of different lengths were investigated with respect to thermal behaviour and morpholo influence of the length of the alkyl side chain and the cooling rate on the morphology, heat of fusion, crystallinity an…
In recent years a great deal of research has focussed on understanding and exploiting self assembling peptides as they form fibrillar hydrogels for use in a variety of different applications, such as tissue engineering and drug delivery. A particular class of such peptide system…
In the present thesis, we propose a modification of silicone surfaces using the controlled deposition of amphiphilic block copolymers from aqueous colloidal dispersions. The surface modifiers are based on poly(dimethylsiloxane) (PDMS) as the hydrophobic part, in order to allow a…
Understanding the supramolecular interactions governing the self-assembly of molecular building blocks upon surfaces is fundamental to the design of new devices such as sensors or catalysts. Successful heterogeneous enantioselective catalysts have relied upon the adsorption of ‘…
The use of low-molecular weight peptide-based hydrogelators (LMWGs) for the immobilisation of enzymes is presented in this thesis. Low-molecular weight hydrogelators are a class of materials which are highly suitable for increasing enzyme lifetimes as they create a suitable biom…
Under specific conditions short peptides modified with an N-terminal fluorenyl-9-methoxycarbonyl (Fmoc) group can self-assemble into hydrogel scaffolds similar in properties to the natural extracellular matrix. Fmoc-diphenylalanine (Fmoc-FF) for instance, has been shown to form …
In this work we have explored the possibility of using surfactant/polyelectrolyte complexes as templates to synthesize inorganic mesostructured materials mainly with a film morphology. Inorganic species deposit in those regions of the films which are filled with a polymer hydrog…
The rational design, synthesis and structural analysis of supramolecular dendrimers that self-assemble into helical pyramidal columns and chiral supramolecular spheres are discussed. Conformationally rigid cyclotriveratrylene is used as a model for crown-like supramolecular asse…
This dissertation is divided into two parts, first deals with the numerical study of motion of dielectric particles subjected to nonuniform electric fields and second deals with the process of self-assembly of particles at fluid-fluid interfaces and subjected to uniform electric…
The overall objective of this work was to synthetize and to characterize polymers that are able to self-assemble in aqueous solution in response to an external trigger. To achieve this goal, we concentrated our efforts on two polymers, poly(2-isopropyl-2-oxazoline) PiPrOx and po…
Hydrogen bond-mediated self-assembling biscarbamates were studied as model compounds of polyurethanes with respect to the crystallization and gelation behaviour in both solid state and solution phase respectively. Systematic investigation of effects of the structural features of…
Self assembly is ubiquitous in nature and design of synthetic systems by imparting the self assembly codes is currently an active area of research. In this thesis, we study the effect of chemically or physically confining a self-assembling molecule on its association in solution…