Thesiss

Estrogens induce renal tumors in the golden Syrian hamster, and serves as a mechanistic model of hormonal carcinogenesis. The goal of this study, is to provide evidence which supports the role of iron in estrogen-induced renal carcinogenesis in the hamster. Male hamsters were tr…

The castrated golden Syrian hamster develops renal adenocarcinoma when subjected to estradiol or diethylstilbesterol (DES) over a nine month period. This tumor is not only estrogen-induced but also estrogen-dependent; therefore, it is considered an experimental model for estroge…

Pituitary tumor transforming gene (PTTG), also known as securing, is a novel oncogene that is expressed at high levels in most of the tumors analyzed to date. Overexpression of PTTG in mouse fibroblast (NIH 3T3) cells increases cell proliferation, induces cellular transformation…