Thesiss

Stress granules are cytoplasmic structures that contain proteins and mRNAs and are formed under stress conditions. It is proposed that SGs promote stress resistance, however the exact mechanism of their formation and function remains unclear. In this study I found that the S6 ki…

The activator of mammalian target of rapamycin complex 1 (mTORC1), Ras homolog enriched in brain (Rheb), is a membrane-associated protein belonging to the Ras subfamily of small GTPases. Rheb's slow GTPase activity is stimulated by the GTPase activating protein (GAP) domain of t…