Inhibiting Cocaine Seeking: Infralimbic Cortical Activity During Extinction Learning and Reinstatement

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Summary

Previous work indicates that the infralimbic cortex (IL) mediates extinction learning and actively suppresses cocaine-seeking during reinstatement, following cocaine self-administration. Despite extensive work supporting this role for IL activity, how and under exactly which conditions the IL negatively modulates cocaine-seeking behavior remains unclear. The present experiments utilized optogenetics and in vivo electrophysiology to probe the role of the IL in modulating cocaine seeking following cocaine self-administration. Rats underwent 6 h-access cocaine self-administration followed by home-cage withdrawal or extinction training. Optogenetic manipulations were employed during cocaine seeking sessions and reinstatement. In vivo electrophysiological recordings were conducted during self-administration, extinction and reinstatement.