Annotation
The inflammasomes
by Couillin, Isabelle, Pétrilli, Virginie, Martinon, Fabio
fromPIR (Series)
The inflammasomes
by Couillin, Isabelle, Pétrilli, Virginie, Martinon, Fabio
fromPIR (Series)
The inflammasome was first described in 2002 as a molecular complex activating proinflammatory caspases and therefore regulating the maturation and biological activities of cytokines such as IL-1b and IL-18. This finding was substantiated by the identification of several mutatio…
Inflammasomes have a seemingly simple architecture. A sensor molecule of the NLR or PYHIN protein family recruits the common adapter molecule apoptosis-associated speck-like protein containing a CARD (ASC). Even so, inflammasome activation is highly regulated at multiple steps…