Cellular and molecular neurophysiology

"This new, thoroughly revised fourth edition is the only current, established and authoritative text focusing on the cellular and molecular physiology of nerve cells. Understanding the functioning of the neuron, the basic cell of the central nervous system requires a clear understanding of the cellular and molecular physiology of the neuron. The book is hypothesis driven rather than just presenting the facts, and the content is firmly based on numerous experiments performed by the top experts in the field. While the book does cover the important facts, it also presents the background for how researchers arrived at this knowledge to provide a context for the field. It teaches not only how excitable cells work in detail, but also how to construct and conduct intelligent research experiments. This book promotes a real understanding of the function of nerve cells that is useful for practicing neurophysiologists and students in a graduate-level course on the topic alike"--OCLC.

Previous edition: 2008.

Cover; Title Page; Copyright Page; Table of Contents; Foreword; Acknowledgments; Part I -- Neurons: Excitable Andsecretory Cells Thatestablish Synapses; Chapter 1 -- Neurons; 1.1 -- Neurons have a cell body from which emerge two types of processes: the dendrites and the axon; 1.1.1 -- The somatodendritic tree is the neuron's receptive pole; 1.1.2 -- The axon and its collaterals are the neuron's transmitter pole; 1.2 -- Neurons are highly polarized cells with a differential distribution of organelles and proteins; 1.2.1 -- The soma is the main site of macromolecule synthesis.

1.2.2 -- The dendrites contain free ribosomes and synthesize some of their proteinsmRNA trafficking and local protein synthesis in dendrites; 1.2.3 -- The axon, to a large extent, lacks the machinery for protein synthesis; 1.3 -- Axonal transport allows bidirectional communication between the cell body and the axon terminals; 1.3.1 -- Demonstration of axonal transport; 1.3.2 -- Fast anterograde axonal transport is responsible for the movement of membranous organelles from cell body towards a ... ; The pioneer living preparation; Identification of the moving organelles and their substrates.

The role of ATP an…