Chemical protein synthesis

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This volume provides updated protocols for chemical protein synthesis. Chapters guide readers through development methods, strategies, and applications of protein chemical synthesis. Written in the format of the highly successful Methods in Molecular Biology series, each chapter includes an introduction to the topic, lists necessary materials and reagents, includes tips on troubleshooting and known pitfalls, and step-by-step, readily reproducible protocols. Authoritative and cutting-edge, Chemi…

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Title Statements

Full title :Chemical protein synthesis / edited by Xuechen Li.

Summary

Edition Statements

Publication Date:2022.

Publication Statements

Publisher(s):Humana Press
Place of Publication:New York, NY
Language:eng
Publication Date:2022.

Notes

Includes index.

The Physical Object

Description:1 online resource (xi, 259 pages) : : illustrations (some color).

Edition Identifiers

ISBN:9781071624890, 107162489X
DOI:10.1007/978-1-0716-2489-0
oclc:on1334605637
LC Classification:QP551
Dewey Decimal:572.645

Sulfated Glycoprotein Synthesis -- Total Chemical Synthesis of a SARS-CoV-2 Miniprotein Inhibitor LCB1 -- Serine/Threonine Ligation and Cysteine/Penicillamine Ligation -- Continuous-flow synthesis of N-Methylated Peptides via Generation of an Acyl N-Methylimidazolium Cation -- Covalent Reactive Peptides to Block Protein – Protein Interactions and Inhibit Microbe-Host Interaction -- Ynamide-Mediated Synthetic Approach to Thioamide Substituted Peptides -- Improved Handling of Peptide Segments Using Side Chain-Based "Helping Hand" Solubilizing Tools -- Helical Stabilization of Peptide Macrocycles by Stapled Architectures -- General solution to the preparation of -thiolated/Selenolated Amino Acids Via Visible Light Catalyzed Asymmetric Giese reaction -- Side-chain Anchoring Strategies for the Synthesis of Peptide Thioesters and Selenoesters -- Preparation of Site-Specific Succinylated Histone Mimics to Investigate Its Impact On Nucleosome Dynamics -- Protein Synthesis Via Activated Cysteine-Directed Protein Ligation -- Sulfonium Tethered Peptide -- PAL-mediated Ligation for Protein and Cell-Surface Modification -- Development of a Glycoform Library-based Strategy to Decipher the Role …