Current progress in iPSC disease modeling

by Birbrair, Alexander

Type Book

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Title Statements

Full title :Current progress in iPSC disease modeling / edited by Alexander Birbrair.

Summary

Current Progress in iPSC Disease Modeling, Volume Fourteen in the Advances in Stem Cell Biology series, is a timely and expansive collection of information and new discoveries in the field. This new volume addresses advances in research on how induced pluripotent stem cells are used for the creation of new tissues and organs. The creation of iPSC technology allowed the development of disease-specific human pluripotent stem cells. These cells allow researchers to study questions once impossible for some human diseases. This volume addresses iPSCs for vascular tissue engineering, bioprinting, derived lung organoids for pulmonary disorders, skeletal muscle engineering, human kidney organoids, and more. It is written for researchers and scientists in stem cell therapy, cell biology, regenerative medicine and organ transplantation, and is contributed by world-renowned authors in the field.

Edition Statements

Publication Date:2022

Publication Statements

Publisher(s):Academic Press
Place of Publication:London
Language:eng
Publication Date:2022

The Physical Object

Description:1 online resource

Edition Identifiers

ISBN:9780323856430, 0323856438
oclc:on1285337554
LC Classification:QH588.S83
Dewey Decimal:616.02774

Front Cover -- Current Progress in iPSC Disease Modeling, Volume 14 -- Advances in Stem Cell Biology -- Current Progress in iPSC Disease Modeling, Volume 14 -- Copyright -- Dedication -- Contents -- Contributors -- About the editor -- Alexander Birbrair -- Preface -- 1 -- Human induced pluripotent stem cell modeling of neurofibromatosis type 1 -- Introduction -- NF1 gene -- Genotype-phenotype correlations -- Roadblocks to treatment -- Nf1 genetically engineered mouse models -- Utility of human induced pluripotent stem cells for NF1 research -- Brain development and function -- Mutational specificity -- Cell-autonomous effects -- Modeling brain development and function -- Nervous system tumors -- Tumor modeling -- Tumor microenvironment -- Other NF1 clinical features -- Future directions -- References -- 2 -- Use of induced pluripotent stem cells to model inflammatory neurodegeneration and repair in multiple sclerosis -- Introduction -- Multiple sclerosis background -- Utility of animal models to study stem cells in multiple sclerosis -- Modeling neurological diseases using stem cells -- Modeling multiple sclerosis with human-derived induced pluripotent stem cells -- Challenges in …