High throughput screening methods: evolution and refinement

by Bittker, Joshua A. Ross, Nathan T.

Type Book

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Title Statements

Full title :High throughput screening methods : evolution and refinement / edited by Joshua A. Bittker, Nathan T. Ross.

Summary

High throughput screening remains a key part of early stage drug and tool compound discovery, and methods and technologies have seen many fundamental improvements and innovations over the past 20 years. This comprehensive book provides a historical survey of the field up to the current state-of-the-art. In addition to the specific methods, this book also considers cultural and organizational questions that represent opportunities for future success. Chapters from leading experts across academia and industry cover initial considerations for screening, methods appropriate for different goals in small molecule discovery, newer technologies that provide alternative approaches to traditional miniaturization procedures, and practical aspects such as cost and resourcing. Within the context of their historical development, authors explain common pitfalls and their solutions.

Edition Statements

Publication Date:2017

Publication Statements

Publisher(s):Royal Society of Chemistry
Place of Publication:Cambridge, UK
Language:eng
Publication Date:2017

The Physical Object

Description:xx, 396 pages : : illustrations.

Edition Identifiers

ISBN:9781782624714, 1782624716
oclc:ocn988024660
LC Classification:RS419.5
Dewey Decimal:615.1/9

HTS methods : assay design and optimisation / David Murray and Mark Wigglesworth -- Considerations related to small-molecule screening collections / Damian W. Young -- Combination screening / Claes R. Andersson, John Moffat and Mats Gustafsson -- Modern biophysical methods for screening and drug discovery / B. Fulroth, V. K. Kaushik and M. F. Mesleh -- Genetic perturbation methods, from the 'awesome power' of yeast genetics to the CRISPR revolution / Gregory R. Hoffman and Dominic Hoepfner -- Understanding luminescence based screens / Simona Gokhin and Douglas S. Auld -- High throughput screening compatible methods for quantifying protein interactions in living cells / M. B. Robers, T. Machleidt and K. V. Wood -- Approaches to high content imaging and multi-feature analysis / C. M. Hale and D. Nojima -- Pharmacological and genetic screening of molecularly characterized cell lines / Zhaleh Safikhani, Heather Selby, Azin Sayad, Christos Hatzis and Benjamin Haibe-Kains -- Multidimensional profile based screening : understanding biology through cellular response signatures / Christopher C. Mader, Aravind Subramanian and Joshua Bittker -- 3D cell culture and dish based organogenesis : …