Inflammation

by Ley, Klaus

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Title Statements

Full title :Inflammation.

Edition Statements

Publication Date:2018.

Publication Statements

Publisher(s):World Scientific Publishing Co Pte Ltd
Place of Publication:Singapore
Language:eng
Publication Date:2018.

Notes

6. Lipidomics of inflammation: Analysis of bioactive lipids.

The Physical Object

Description:1 online resource (373 pages)

Edition Identifiers

ISBN:9789813109445, 9813109440
oclc:on1031963815
Dewey Decimal:616.0473

Intro; Contents; Chapter 1 TNF Superfamily in Inflammation; 1. Introduction; 1.1. Discovery of TNF and lymphotoxin; 1.2 Description of TNFSF proteins; 1.2.1. TNFSF ligands; 1.2.2. TNF receptors superfamily; 1.2.3. Ligand-receptor binding models; 1.2.4. The lymphotoxin and tumor necrosis factor network; 1.3. Signaling pathways; 1.3.1. The TNF-TNFR pathway; 1.3.2. LTbR signaling and the alternative NF-kB pathway; 2. TNFSF and inflammation; 2.1. Acute inflammation; 2.2. Chronic inflammation and autoimmunity; 2.3. TNFSF signatures in human pathologies; 2.3.1. Rheumatoid arthritis.

2.3.2. Inflammatory bowel disease2.4. Experimental models and the TNFSF as drug targets; 3. Targeting TNFSF in the clinic; 3.1. TNF inhibitors; 3.2. Other TNFSF targets; 4. Summary; Acknowledgements; References; Chapter 2 Complement as a Mediator of Inflammation; 1. Introduction to the complement system; 1.1. What is complement?; 1.2. Initiation of complement activation; 1.3. Amplification in the activation pathways; 1.4. The amplification loop of the alternative pathway; 1.5. Amplification at the stage of C5 cleavage; 1.6. Assembly of the membrane attack complex.

1.7. Active products of complement activat…