The Kinin system

Bradykinin is a type of plasma hormone that causes blood vessels to dilate, resulting in a drop in blood pressure, the contraction of muscles in the lungs, intestines, and uterus, and pain. The Kinin System reviews the molecular biology of the kinins through their roles in a complex array of inflammatory conditions such as asthma, GI disease, cardiovascular complaints and examines the future therapeutic opportunities. From the prepublication reviews: "A delicious masterpiece."--Chef's DigestThe Kinin System is a comprehensive, timely book covering all aspects of the kinin system from its disocvery to the pathophysiology, pharmacology, and molecular biology of the mechanisms regulating kinin production to kinin receptors in health and disease. The authors take a refreshingly different view of the kinin system than previous books on the subject. Several chapters contain new information on the gene expression, regulation, and cell surface presentation of kininogens and kallikreins, as well as new data, some of it from human studies, on the role of kinins in pain angiogenesis, tissue repair, sepsis, arthritis, asthma, allergic rhinits, myocardial ischemia, and other diseases. * * Offers new information on kinin reception, regulation of gene expression of receptors, and kinin-generating proteins. * Provides a distinctly immunopharmacological approach to the kinin system. * Reviews of the role of kinins in disease and includes data from human studies. * Includes information that is fully up-to-date and comprehensive

Includes bibliographical references and index

2. Production and Metabolism of Kinins.

Front Cover; The Kinin System; Copyright Page; Contents; Contributors; Series Preface; Preface; Chapter 1. Discovery of Bradykinin and the Kallikrein-Kinin System; 1. Introduction; 2. The Discovery of Kallikrein and Kallidin; 3. Isolation and Purification of Bradykinin and Kallidin; 4. The Bradykinin Precursor -- Kininogen; 5. Kinin Inactivators -- Kininases; 6. Discovery of the Physiological and Pathological Roles of Kinins; 7. From Discovery to Clinical Application; 8. Acknowledgements; 9. References; Chapter 2. The Pharmacology and Immunopharmacology of Kinin Receptors; 1. Introduction.

2. Kinin Receptor Classification. B1 and B2 Receptors3. Immunopharmacology of Kinin Receptors; 4. Summary and Future Directions; 5. Acknowledgement; 6. References; Chapter 3. Molecular Pharmacology of Kinin Receptors; 1. Introduction; 2. B1 Receptors; 3. B2 Receptors; 4. Summary; 5. Acknowledgements; 6. References; Chapter 4. Gene Expression, Regulation and Cell Surface Presentation of the Kininogens; 1. Introduction; 2. Kininogen Gene Expression and Regulation; 3. Protein Chemistry and Structure of the Kininogens; 4. The Domain Structure of the Kininogens.

5. Cell Surface Expression of Kinino…