Introduction to Antibody Engineering

by Rüker, Florian Wozniak-Knopp, Gordana

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Title Statements

Full title :Introduction to Antibody Engineering / edited by Florian Rüker, Gordana Wozniak-Knopp.

Summary

This highly readable textbook serves as a concise and engaging primer to the emerging field of antibody engineering and its various applications. It introduces readers to the basic science and molecular structure of antibodies, and explores how to characterize and engineer them. Readers will find an overview of the latest methods in antibody identification, improvement and biochemical engineering. Furthermore, alternative antibody formats and bispecific antibodies are discussed. The book's content is based on lectures for the specializations "Protein Engineering" and "Medical Biotechnology" within the Master's curriculum in "Biotechnology." The lectures have been held at the University of Natural Resources and Life Sciences, Vienna, in cooperation with the Medical University of Vienna, since 2012 and are continuously adapted to reflect the latest developments in the field. The book addresses Master's and PhD students in biotechnology, molecular biology and immunology, and all those who are interested in antibody engineering.

Edition Statements

Publication Date:2021.
Edition:1st ed. 2021

Publication Statements

Publisher(s):Imprint: Springer, Springer International Publishing
Place of Publication:Cham
Language:eng
Publication Date:2021.

The Physical Object

Description:1 online resource (VIII, 388 p. 69 illus., 52 illus. in color. :) : online resource.

Edition Identifiers

ISBN:9783030546304, 3030546306, 9783030546298, 3030546292, 9783030546311, 3030546314
DOI:10.1007/978-3-030-54630-4
oclc:on1253416288
LC Classification:QR186.7-186.85
Dewey Decimal:571.967

Chapter 1. Introduction by the editors -- Chapter 2. Antibodies -- A History of their Discovery and Properties -- Chapter 3. Monoclonal Antibodies and Hybridomas -- Chapter 4. Antibody Display Systems -- Chapter 5. Transgenic Animals for the Generation of Human Antibodies -- Chapter 6. Applications of Antibodies in Therapy, Diagnosis & Science -- Chapter 7. Bispecific antibodies -- Chapter 8. Antibody-Drug Conjugates -- Chapter 9. Alternative Binding Scaffolds -- multipurpose binders for applications in basic research and therapy -- Chapter 10: Chimeric antigen receptor (CAR) redirected T cells -- Chapter 11. Improvement of Key Characteristics of Antibodies -- Chapter 12. Engineering therapeutic antibodies for development -- Chapter 13. Eukaryotic expression systems for upstream pro-cessing of monoclonal antibodies -- Chapter 14. Antibody Validation.