Mouse models for drug discovery: methods and protocols

by Festing, Michael F. W. Proetzel, Gabriele Wiles, Michael V.

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Title Statements

Full title :Mouse models for drug discovery : methods and protocols / edited by Gabriele Proetzel (Takeda Pharmaceutical Company, Cambridge, MA, USA), Michael V. Wiles (The Jackson Laboratory, Bar Harbor, ME, USA).

Summary

"With genetic engineering, systems explored in this book now exist allowing for the simple, efficient, and near universally precise genetic manipulation directly in any organism, including the mouse. Herein, these models are applied to a wide field of disease areas, including diabetes, cardiovascular disease, skin disorders, cancer, neurodegenerative and neuromuscular diseases, retinal disorders, as well as various behavioral models. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Practical and fully updated, Mouse Models for Drug Discovery: Methods and Protocols, Second Edition serves to equip the reader with an extensive overview of techniques to utilize the many possibilities of mice in the drug development process."--OCLC.

Edition Statements

Publication Date:2016.
Edition:Second edition

Publication Statements

Publisher(s):Humana Press
Place of Publication:New York
Language:spa
Publication Date:2016.

The Physical Object

Description:1 online resource (1 recurs en línia (xi, 436 pàgines) :) : : il·lustracions (algunes en color).

Edition Identifiers

ISBN:9781493936618, 1493936611
oclc:ocn970444538

Conté: Genetically Defined Strains in Drug Development and Toxicity Testing / Michael F.W. Festing -- Simple, Efficient CRISPR-Cas9-Mediated Gene Editing in Mice: Strategies and Methods -- Mouse Sperm Cryopreservation and Recovery of Genetically Modified Mice -- Generation of Immunodeficient Mice Bearing Human Immune Systems by the Engraftment of Hematopoietic Stem Cells -- Generation of Human Liver Chimeric Mice for the Study of Human Hepatotropic Pathogens -- Human FcRn Transgenic Mice for Pharmacokinetic Evaluation of Therapeutic Antibodies -- A Humanized Mouse Model to Study Human Albumin and Albumin Conjugates Pharmacokinetics -- Germ-Free Mice Model for Studying Host-Microbial Interactions -- Bridging Mice to Men: Using HLA Transgenic Mice to Enhance the Future Prediction and Prevention of Autoimmune Type 1 Diabetes in Humans -- David V. Serreze, Marijke Niens, John Kulik, and Teresa P. DiLorenzo 10 Mouse Models of Type 2 Diabetes Mellitus in Drug Discovery -- Helene Baribault 11 Cholesterol Absorption and Metabolism -- Skin Diseases in Laboratory Mice: Approaches to Drug Target Identification and Efficacy Screening -- Chronic Myeloid Leukemia (CML) Mouse Model in Translatio…