Principles of proteomics

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'Principles of Proteomics' covers the development of large-scale technologies for protein separation, isolation, detection and quantification. It provides a comprehensive introduction to this relatively new field.

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Title Statements

Full title :Principles of proteomics / Richard M. Twyman.

Summary

Edition Statements

Publication Date:©2014.
Edition:Second edition

Publication Statements

Publisher(s):Garland Science
Place of Publication:New York
Language:eng
Publication Date:©2014.

The Physical Object

Description:xi, 260 pages : : color illustrations ; : 28 cm

Edition Identifiers

ISBN:9780815344728, 0815344724
oclc:ocn843856412
LC Classification:QP551
Dewey Decimal:572/.6

Chapter 1 The origin and scope of proteomics. 1.2 THE BIRTH OF LARGE-SCALE BIOLOGY AND THE "OMICS" ERA ; 1.3 THE GENOME, TRANSCRIPTOME, PROTEOME, AND METABOLOME ; 1.4 FUNCTIONAL GENOMICS ; Transcriptomics is the systematic, global analysis of mRNA ; Large-scale mutagenesis and interference can also determine the functions of genes on a global scale ; 1.5 THE NEED FOR PROTEOMICS ; 1.6 THE SCOPE OF PROTEOMICS ; Protein identification and quantitation are the most fundamental aspects of proteomic analysis ; Important functional data can be gained from sequence and structural analysis ; Interaction proteomics and activity-based proteomics can help to link proteins into functional networks ; 1.7 CURRENT CHALLENGES IN PROTEOMICS -- Chapter 2 Strategies for protein separation. 2.2 GENERAL PRINCIPLES OF PROTEIN SEPARATION IN PROTEOMICS ; 2.3 PRINCIPLES FOR TWO-DIMENSIONAL GEL ELECTROPHORESIS ; Electrophoresis separates proteins by mass and charge ; Isoelectric focusing separates proteins by charge irrespective of mass ; SDS-PAGE separates proteins by mass irrespective of charge ; 2.4 THE APPLICATION OF 2DGE IN PROTEOMICS ; The four major advantages of 2DGE are robustness, reproducibility,…