Title Statements
- Full title :Progress in Medicinal Chemistry.
Edition Statements
- Publication Date:2017.
Publication Statements
- Publisher(s):Elsevier Science
- Place of Publication:Saint Louis
- Language:eng
- Publication Date:2017.
The Physical Object
- Description:1 online resource (196 pages)
Edition Identifiers
- ISBN:9780444639431, 0444639438
- oclc:ocn979159308
- LC Classification:RS403
- Dewey Decimal:615.19
Table of Contents
Front Cover; Progress in Medicinal Chemistry; Copyright; Contents; Contributors; Preface; Chapter One: Enabling Chemistry Technologies and Parallel Synthesis-Accelerators of Drug Discovery Programmes; 1. Introduction; 2. The Evolution of Flow-Based Approaches to Synthesis; 3. Use of High-Temperature Chemistries; 4. Use of Photochemical and Electrochemical Reactions; 5. Use of Hazardous Gases (e.g. Diazomethane) in Flow; 6. Library Design Tools and Processes; 7. Use of Flow Chemistry for Library Synthesis; 8. Summary and Future Perspectives; Acknowledgements; References.
Chapter Two: Development of LRRK2 Inhibitors for the Treatment of Parkinsonś Disease1. Introduction; 2. LRRK2 Biology; 2.1. Genetic Evidence for the Possible Role of LRRK2 in PD; 2.2. Localisation and Function of LRRK2; 3. Structural Biology of LRRK2; 4. Overview of Selective Inhibitors of LRRK2; 4.1. Diaminopyrimidines; 4.2. Arylbenzamides; 4.3. Indolinones; 4.4. Indazoles; 4.5. Cinnolines/Quinolines; 4.6. Pyrrolopyrimidines; 4.7. Thiophenes; 4.8. Triazolopyridazines; 5. Conclusion; References; Chapter Three: Recent Progress in the Discovery and Development of TRPA1 Modulators.
1. TRPA1: An Introduction2. Valida…
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