Systems biology: modeling, analysis, and simulation
by Lei, Jinzhi
This book discusses the mathematical simulation of biological systems, with a focus on the modeling of gene expression, gene regulatory networks and stem cell regeneration. The diffusion of morphogens is addressed by introducing various reaction-diffusion equations based on different hypotheses concerning the process of morphogen gradient formation. The robustness of steady-state gradients is also covered through boundary value problems. The introduction gives an overview of the relevant biolog…
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- Full title :Systems biology : modeling, analysis, and simulation / Jinzhi Lei.
Summary
This book discusses the mathematical simulation of biological systems, with a focus on the modeling of gene expression, gene regulatory networks and stem cell regeneration. The diffusion of morphogens is addressed by introducing various reaction-diffusion equations based on different hypotheses concerning the process of morphogen gradient formation. The robustness of steady-state gradients is also covered through boundary value problems. The introduction gives an overview of the relevant biological concepts (cells, DNA, organism development) and provides the requisite mathematical preliminaries on continuous dynamics and stochastic modeling. A basic understanding of calculus is assumed. The techniques described in this book encompass a wide range of mechanisms, from molecular behavior to population dynamics, and the inclusion of recent developments in the literature together with first-hand results make it an ideal reference for both new students and experienced researchers in the field of systems biology and applied mathematics.
Read More ↓Edition Statements
- Publication Date:©2021
Publication Statements
- Publisher(s):Springer
- Place of Publication:Cham, Switzerland
- Language:eng
- Publication Date:©2021
The Physical Object
- Description:xii, 308 pages : : illustrations (some color) ; : 24 cm
Edition Identifiers
- ISBN:3030730328, 9783030730321
- oclc:on1241244288
- LC Classification:QH323.5
- Dewey Decimal:570.1/13
Table of Contents
1. Biological Background-information, Energy, and Matter -- 2. Mathematical Preliminary continuous Dynamics -- 3. Mathematical Preliminary-stochastic Modeling -- 4. Stochastic Modeling of Gene Expression -- 5. Mathematical Models for Gene Regulatory Network Dynamics -- 6. Dynamical Modeling of Stem Cell Regeneration -- 7. Mathematical Models of Morphogen Gradients and Growth Control.
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