The medicinal chemist's guide to solving ADMET challenges

The Medicinal Chemist's Guide to Solving ADMET Challenges summarizes a series of design strategies and tactics that have been successfully employed across pharmaceutical and academic laboratories to solve common ADMET issues. These are exemplified with a curated collection of concrete examples displayed in a highly visual "table-of-contents" style format, allowing readers to rapidly identify the most promising approaches applicable to their own challenges. Each ADMET parameter is introduced in a concise yet comprehensive manner and includes background, relevance and screening strategies. Medicinal chemistry knowledge of how best to modify molecular structure to solve ADMET issues is challenging to retrieve from the literature, public databases and even corporate data warehouses. The Medicinal Chemist's Guide to Solving ADMET Challenges addresses this gap by presenting state-of-the-art design strategies put together by a global group of experienced medicinal chemists and ADMET experts across academia and the pharmaceutical industry.

Overview of Strategies for Solving ADMET Challenges / Patrick Schnider -- Tactics to Improve Solubility / Robert J. Young -- Optimisation of Passive Permeability for Oral Absorption / Andy Pike and R. Ian Storer -- Targeting Gastrointestinal Uptake Transporters / Simone H. Stahl, Katherine S. Fenner, M. Raymond V. Finlay, Ravindra V. Alluri, Beth Williamson, Johan X. Johansson and Jason Kettle -- Drug Efflux Transporters: P-gp and BCRP / Peter Bungay and Sharan Bagal -- OATs and OCTs: The SLC22 Family of Organic Anion and Cation Transporters / Pär Matsson and Maria Karlgren -- OATPs: The SLCO Family of Organic Anion Transporting Polypeptide Transporters / Maria Karlgren and Pär Matsson -- Bile Salt Export Pump (BSEP) Inhibition / Alexander Treiber and Martin H. Bolli -- Cytochrome P450 Metabolism / Antonia F. Stepan and R. Scott Obach -- Cytochrome P450 Induction / Hua Lv, Wei Zhu and Hong Shen -- Strategies to Mitigate CYP450 Inhibition / Alexander G. Dossetter, Marcel J. de Groot and Sarah E. Skerratt -- Aldehyde and Xanthine Oxidase Metabolism / David C. Pryde, Dharmendra B. Yadav and Rajib Ghosh -- Glucuronidation / Yue Pan -- Sulfation / Yue Pan -- Reactive Metabolites / Amit…