Rasnick, who worked in the pharmaceutical/biotech industry to develop protease inhibitors and founded three biotech companies, explains the chromosomal imbalance (aneuploidy) theory of cancer, as opposed to the gene mutation theory. He describes how gene mutations are not powerf…
Aneuploidy can have contradictory effects on organisms and cells, from developmental disorders and cancer in humans to drug resistance and adaptive advantage in yeast. Despite a long history of involvement in human health and innumerable cases in other model organisms, how aneup…
Mutations in the STAG2 gene are present in approximately 20% of tumors from different tissues of origin. STAG2 encodes a subunit of the cohesin complex, and tumors with loss of function mutations are usually aneuploid and display elevated frequencies of lagging chromosomes durin…
Most solid tumors are aneuploid and frequently mis-segregate chromosomes during cell division. This chromosomal instability frequently arises from persistent mal-oriented attachments of chromosomes to spindle microtubules at kinetochores. The defects in cancer cells that prevent…
This book presents Down syndrome, which is the most common chromosomal disorder in humans, occurring at a rate of about 1 in 700 births. The book describes the characteristic physical features caused by Down syndrome and the myriad of symptoms and health complications it brings,…