In this thesis the representation of speech sounds in the auditory system is modeled, in order to determine how the underlying mechanisms affect speech perception, and more specifically to understand the staged transformations at different levels of the auditory system that resu…
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We have developed a carrier system to encapsulate Indocyanine Green (ICG) to overcome its limitations for laser-mediated medical applications. Charge-assembled capsules with controllable size and adjustable coatings efficiently encapsulate ICG and effectively stabilize its optic…
We have developed a series of novel techniques, adapted from the field of tumor biology, to quantify vascular structure and function and to explore the role of Angiotensin (Ang) II receptor AT1 in cardiac remodeling post myocardial infarction (MI). We examined the scar neovascul…
Ozone (O3), a highly reactive gas, is the major component of photochemical smog and causes a reproducible heterogeneous pattern of lung injury. We hypothesize that this spatial distribution of lung injury mirrors an analogous distribution of O3 dose delivered to different tissue…
There are over 10 million peoples in the world who are blind for retinal diseases. On the other hand, 300,000 people are profoundly deaf in America. This dissertation is undertaken to help these people and contribute to the development of neural prosthesis. Research are carried …
Growth hormone deficiency has benefited immensely from the effective use of growth hormone replacement therapy. Recently the manufacture of recombinant human growth hormone (RHGH) has increased evaluation of the therapeutic value of growth hormone beyond the treatment of growth …
Background. Iron deficiency is the most common preventable nutrition problem in developing countries today. Enough is known about iron metabolism that a computer model should be able to predict individual responses to iron supplementation. If construction of such a valid model w…
A novel interactive technique for whole-body magnetic resonance (MR) imaging and lower limb angiography was developed. This approach scans an extended or large field-of-view (FOV) which may potentially allow imaging of the entire human body in a single MR procedure. Large FOV im…
Characterizing and understanding three-dimensional natural phenomena (e.g. the energy budget of a forest canopy) requires massive parallel sensing and data processing. Static wireless sensor networks enable sampling of the environment at a finer granularity than ever before to i…
We hypothesize that localized irradiation of solid tumors results in inflamed vasculature leading to an over-expression of various adhesion molecules. These adhesion molecules can then be targeted to selectively deliver antivascular drugs to irradiated tumors and delay tumor gro…
Laser-scanning microscopy (LSM) has become a standard technique for biomedical imaging at the cellular and sub-cellular level. LSM is not only widely used as a powerful biological imaging tool but also as a research platform for investigating new imaging modalities. However, eme…
Arterial pulse pressure is critically important to a number of diseases such as isolated systolic hypertension, coronary artery disease and heart failure. Determining the cause of increased pulse pressure has been hampered for two reasons. First, pulse pressure results from cont…
Segmentation is an important step in the interpretation of Magnetic Resonance (MR) images of the human body. MRI reveals an unequaled view of the anatomy of the brain in terms of spatial and contrast resolution, and its multispectral nature has been exploited to obtain better pe…
Composites that contain hydrophilic particles dispersed uniformly within a hydrophobic network have been investigated. Theoretical issues that governed release characteristics have been defined and validated experimentally. When the hydrophilic content is below the percolation t…
Implants of tricalcium phosphate ceramic (Ca\sb3(PO\sb4)\sb2, TCP) and hydroxyapatite (Ca₁₀(PO\sb4)\sb6(OH)\sb2, HAP) labelled with Ca⁴⁵ were implanted into long bones of turkeys for up to six months. These synthesized compounds are analogues of biologically relevant minerals th…
Currently, the surgeon operating with the Zeus robot relies exclusively on visual feedback from the surgical site. However, the sense of touch may be extremely important for the surgeon because certain tissue is very delicate and cannot withstand a large amount of force exerted …
Bone homeostasis, fracture, and fracture healing process identification, modeling, control and simulation using soft computing methodologies are presented. Although the focus is on the fracture healing process, models of bone homeostasis and fracture occurrence are developed to …
Background. An acute myocardial infarction (MI) is one of the more common diagnoses for hospitalized patients in America. In treating this disease, physicians commonly have several different treatment regimens available. A decision support system that could identify patients at …
Advances in materials technology have brought about a class of prostheric foot and ankle components for the lower limb amputee, called Dynamic Elastic Response (DER). These components are designed to store energy during the stance phase of gait in a leaf spring keel, and return …