Cancer is the second leading cause of death in Canada and in the United States. Over 50% of cancer patients will receive radiation therapy as a part of or all of their treatment. In order to ensure proper tumour coverage and normal tissue avoidance, accurate dose verification is…
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We have studied the arrhythmia problem and acquired the clinical knowledge to detect arrhythmia events accurately. We have also determined what clinical knowledge is used and what clinical knowledge is ignored by existing ECG beat classifiers. Both ECG beat classifiers and clini…
Development of small-diameter blood vessels using tissue engineering has been promising as a novel therapy for patients who require coronary artery bypass grafting but lack suitable donor tissue. However, the performance of tissue engineered vascular grafts (TEVGs) has been chal…
In order to simulate ultrasound propagation and subsequent thermal effects in biological media in which blood vessels and other structures may be present, a 3-dimensional model has been developed that eliminates the need for symmetry constraints. The model is based on the couple…
High Intensity Focused Ultrasound, or HIFU, is capable of treating tissue deep in the body without the need for surgery. With this premise, an ultrasound image-guided HIFU device has been developed for treating submucosal uterine fibroids, which are benign tumors common in women…
Automatic Target Recognition (ATR) is an important issue in many military and non-military applications. ATR generally refers to the use of computer processing to detect and recognize target signatures in sensor data. One of the applications of ATR that has drawn a lot of attent…
The delivery of therapeutic DNA to patients with genetic or acquired disorders has evolved into a realistic alternate treatment to surgery, drug delivery, or as an adjuvant to therapies. A specific area of this research is to transduce CD34+ cells with therapeutic DNA containing…
In spite of the prevalence of wrist disorders, the three dimensional kinematics of the wrist bones in pathological conditions is poorly understood. The purpose of this study was to develop a method to visualize and quantify in vivo three-dimensional carpal bone, radius, and ulna…
Interaction of electromagnetic fields with human tissues, particularly the brain, is of great interest in omnipresent wireless communications. A field analysis (e.g., FDTD) requires knowledge of the complex permittivity of tissues exposed to the electromagnetic radiation. Howeve…
Vinylbenzylphosphonate ester (VBP) was homopolymerized and copolymerized with methyl methacrylate and the reactivity ratio of this pair of monomers was calculated from Finneman-Ross and Kelen-Tudos methods. These methods provided identical values, which are r\sb1 (VBP) = 1.23 an…
In the first part of this dissertation, a new apparatus was designed to produce equi-biaxial dynamic stretches with area changes ranging from 0 to 55% and frequencies ranging from 0 to 2 Hz. Homogeneous finite strain analysis using triangles of markers was performed to compute t…
Nucleolin, an abundant cellular protein, has been recognized as a therapeutic target in gene therapy treatments for cancer. Structural studies to facilitate rational design of small molecule inhibitors of nucleolin require sufficient quantities of the protein. Since cellular lev…
Treatment of breast cancer is currently effective only if it is detected at an early stage. X-ray mammography is the most effective method for early detection, however, mammographic images are complex. Researchers have been utilizing image processing and image analysis technique…
Bone's ability to respond relatively high frequencies of mechanical stimuli is indicative as to how bone cells sense the signal for adaptation. This frequency sensitivity data extends beyond identifying the factor that stimulates bone formation. The most active inhibitor of bony…
A new role is proposed for the superior colliculus within the feedback loop of the brainstem saccade generator in light of identification of buildup neurons within the superior colliculus. The Dominey-Arbib model of spatial accuracy is taken as a platform and is modified to acco…
Herpes simplex virus type-1 (HSV-1) represents an ideal vector for use in many gene therapy applications. HSV-based vectors have recently been employed in human clinical trials to treat malignant brain tumors. The production of HSV-1 vectors must now be scaled-up to meet the dem…
Kerosene-based fuels have been used for many decades. Over 2 million military and civilian personnel each year are occupationally exposed to various jet fuel mixtures. Dermatitis is one of the major health concerns associated with these exposures. In the past, separate absorptio…
Background The use of emergency contraception (EC) in the United States has increased over time but has not had the public health impact on the incidence of unintended pregnancy that was originally envisioned at the time of its FDA approval. The lack of impact may partially be e…
The purpose of this study was to determine trunk muscle performance in the sitting, semi-standing and standing postures during isometric and dynamic extension and flexion movements. Twenty male subject volunteers with no previous history back pain for the past six months partici…
Two experiments were performed with live turkeys to investigate the nature of adaptive bone remodeling, i.e., the relationship between bone strains and bone morphology. Three birds were trained to hop on one leg during short sessions while otherwise walking normally; the exercis…