This dissertation explores the role of the respiratory CO2 feedback system of man in producing breath-to-breath correlated and periodic variations in ventilation. The major hypothesis is that continuous random disturbances to the respiratory CO2 chemical control system can lead …
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There has been considerable interest in noninvasive detection and imaging of dipolar electric current distribution in volume conductors. Application of this technique would include bioelectric current imaging for the purpose of gaining insight into the physiologic process and ab…
In this thesis, the idea of integrating personal computers (PC's) and digital signal processing boards (DSP) to acquire and analyze the electrocardiographic (ECG) signals is achieved. The main part of the thesis is concerned with acquiring data from the ECG leads. A hardware des…
For phased array medical ultrasound imaging, digital beamforming techniques and VLSI circuits are studied to form a fully digital receive front-end hardware. To increase the timing accuracy in beamforming, a computationally efficient upsampling scheme is examined. A digital beam…
The feasibility of encapsulating in vitro fertilized embryos prior to transfer in order to improve pregnancy rates for human in vitro fertilization and embryo transfer was examined. The effect of encapsulation on in vitro embryonic cleavage rates, implantation rates and fetal de…
A computer based system was designed and used to collect physiologic and respiratory data (13 variables and 3 waveforms) from six routinely used operating room monitors. 23 hours of data were collected during 20 general surgery cases (ASA III patients). Part of the data were use…
One of the major difficulties in identifying internal tissue structures with current ultrasonic methods if the lack of quantitative and complete retrieval of the acoustical parameters of tissue by a single technique. Therefore, a mathematical model representing the ultrasonic si…
Herpes simplex virus type 1 (HSV-1) is a promising vector for gene therapy applications. To be used as therapeutic agents, HSV-1 vectors must meet the stringent criteria of high titer and purity. Thus, development of scalable, efficient HSV-1 vector purification strategies is es…
It is well established that diabetes is of critical importance in the world as the number of people affected increases globally. Although a great deal is known about the pancreas and its function, there are still unanswered basic questions about normal pancreatic physiology/func…
As explosive blasts continue to cause casualties in both civil and military environments, there is a need for increased understanding of the mechanisms of blast trauma at the organ level and a need for a more detailed predictive methodology. A fundamental understanding of blast …
Ultra high molecular weight polyethylene is the bearing surface of choice for implants, but because of wear, it is often a limiting factor for the longevity of the implant. Understanding the wear potential of new implants such as the total disc replacement (TDR) is critical due …
Implantable cardioverter defibrillators can terminate accelerated heart rhythms with either high energy shocks or antitachycardia pacing. Shocks are highly effective, but they reduce the quality of life in patients that receive them. Antitachycardia pacing is a train of pulses a…
Sleep-Disordered Breathing (SDB) is estimated to have a prevalence of 5% in middle-aged population. The population is widely thought to be under diagnosed, since the present method to detect and diagnose SDB, Nocturnal Polysomnography (NPSG), is still expensive and not accessibl…
Swallowing function is a complicated process involving several highly coordinated events. In recent years, acoustical analysis of the swallowing mechanism has received considerable attention due to its diagnostic potentials. This thesis presents novel approaches for analysis and…
The purpose of this study was to investigate the effectiveness of a personal lift augmentation device (PLAD) at reducing the spinal loading at the L4/L5 joint during lifting tasks. The PLAD is an on-body ergonomic aid that has elastic elements that lie external to the erector sp…
The goal of this research is to design and build a more life-like prosthesis with a higher degree of freedom than currently available prosthetic devices. Direct brain monitoring of the motor cortices was selected as a control mechanism that would provide more versatility than th…
"Praise for Computational Systems BiologyApproaches in Cancer Research: "Complex concepts are written clearly and with informative illustrations and useful links. The book is enjoyable to read yet provides sufficient depth to serve as a valuable resource for both students and fa…
