Rasnick, who worked in the pharmaceutical/biotech industry to develop protease inhibitors and founded three biotech companies, explains the chromosomal imbalance (aneuploidy) theory of cancer, as opposed to the gene mutation theory. He describes how gene mutations are not powerf…
Mutations in the STAG2 gene are present in approximately 20% of tumors from different tissues of origin. STAG2 encodes a subunit of the cohesin complex, and tumors with loss of function mutations are usually aneuploid and display elevated frequencies of lagging chromosomes durin…
The basic goals of my work are to understand and characterize biological pathways that are altered in cancer. In particular, I have been focusing on colorectal cancer. In my work I used various supervised and unsupervised computational methods to analyze high-throughput data suc…
Persistent Aurora (Aur) A and B over-expression, centrosome amplification (CA), chromosomal instability (CIN) and aneuploidy invariably occur together in a vast majority of human neoplasms. These molecular changes are frequently found (>80%) in human sporadic ductal carcinoma in…
