Homocysteine (Hcy) has been identified as a primary risk factor for atherosclerosis as it induces endothelial cell (EC) activation/dysfunction and thus potentially initiating atherosclerotic plaque formation. There is accumulating evidence indicating a key role for oxidative str…
"156" Result
Sort By:
Cytokine based therapies can be targeted to the sites of active inflammation by modifying a given cytokine as a LAP-cytokine. IL-17A has been shown to directly contribute to pathogenesis of rheumatoid arthritis (RA). IL-17F, another member of the IL-17 cytokines family shares st…
The transcription factor NF-kB has long been known to play a central role in the immune system by regulating the expression of key genes. Moreover, activation of this transcription factor helps a wide variety of cell types survive damage induced by pro-apoptotic stimuli. Owing t…
The transcription factor NF-kB has long been known to play a central role in the immune system by regulating the expression of key genes. Moreover, activation of this transcription factor helps a wide variety of cell types survive damage induced by pro-apoptotic stimuli. The lin…
The transcription factor NF-kB has long been known to play a central role in the immune system by regulating the expression of key genes. Moreover, activation of this transcription factor helps a wide variety of cell types survive damage induced by pro-apoptotic stimuli. Owing t…
The Influenza A Virus (IAV) employs a variety of strategies in order to disarm the host immune response, most of which are carried out by the non-structural 1 protein encoded in the eighth viral genome segment. One such strategy is to blunt the innate immune response by preventi…
Multiple sclerosis (MS) is the most common cause of acquired neurological disability in young adults. It is a multifocal disease defined histologically by multiple inflammatory lesions of demyelination, axonal injury, astrogliosis and varying degrees of remyelination. MS has two…
Interferons (IFNs) are a family of cytokines that elicit pleiotropic effects on virtually all cell types. The type I sub-family is comprised of 17 homologous members that signal through a single shared receptor, which is composed of the two transmembrane proteins IFN Receptor (I…
