This volume explores the mechanisms of resistance to targeted therapeutics.¡The focus is on the cancer cell signaling network, ¡although other mechanisms of resistance including target¡mutation, and new areas of study such as cancer stem cells are included.¡ Targeted Therapies: …
Cyclic nucleotide phosphodiesterases (PDEs) are promising targets for pharmacological intervention. Multiple PDE genes, isoform diversity, selective expression and compartmentation of the isoforms, and an array of conformations of PDE proteins are properties that challenge devel…
This volume provides information related to the difficulties in treating cancers through targeted drug delivery. It examines our current understanding of cancer biology as well as potential technologies that may achieve enhanced drug delivery to tumors.
Ocular transporters and receptors contains detailed descriptions of major transporters and receptors expressed in the eye, with special emphasis on their role in drug delivery. The complex anatomy and the existence of multiple barriers in the eye pose a considerable challenge to…
Contains detailed descriptions of major transporters and receptors expressed in the eye, with special emphasis on their role in drug delivery. Key topics covered include the anatomy and physiology of the eye, biology of ocular transporters and receptors and techniques in their c…