In this thesis we investigate the mechanisms underlying the generation of abnormal EEG rhythms in epilepsy, which is a crucial step towards better treatment of this disorder in the future. To this end, macroscopic scale mathematical models of the interactions between neuronal po…
Background: It is often considered that, following paediatric acquired brain injury (pABI) and epilepsy, higher-level cognitive deficits, such as prospective memory (PM), are impaired and may only become apparent over time when these abilities are expected to develop and mature …
Background: Despite the so-called "generalised" nature of many epileptic seizures, patient specific spatio-temporal properties have been shown using imaging data at the macroscopic level of the cortex. Previous computational models have failed to account for spatial heterogeneit…
People with learning disabilities constitute about 2% of the general population. Epilepsy is more prevalent among people with learning disabilities compared with the general population. Effective communication is central to the management of people with learning disabilities and…
Epilepsien gehren zu den hufigsten chronischen Erkrankungen des zentralen Nervensystems und betreffen mit einer Prvalenz von 1% einen recht hohen Teil der Bevlkerung. Epilepsien sind nicht nur unmittelbar durch die Anflle von Bedeutung, sie sind es auch mittelbar, weil sie Probl…
Die Behandlung von epilepsiekranken Frauen wChrend der Schwangerschaft ist eine hCufige und wichtige Beratungssituation in der Neurologie und GynCkologie. Auch endokrine StC6rungen, verursacht durch die Erkrankung oder die Medikation, mussen therapeutisch berucksichtigt werden, …
Deep brain stimulation and epilepsy
Deep brain stimulation has been used effectively for many years to treat patients suffering from Parkinson's disease. Now, neurologists and neurosurgeons are using electric pulse generators to block abnormal activity, i.e. epileptic fits. Promising research results indicate that…
PET and SPECT in Neurology
What's the difference between being possessed by Satan and hallucinating that you're possessed by Satan? To an 11-year old boy who's heard all about The Exorcist, nothing at all. Go to Hell and back with Steve Kissing in this autobiographical graphic novel that proves that real …